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Short one-pot chemo-enzymatic synthesis of L-lysine and L-alanine diblock copolypeptides
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-1922-128X
(English)Manuscript (preprint) (Other academic)
Identifiers
URN: urn:nbn:se:kth:diva-136997OAI: oai:DiVA.org:kth-136997DiVA: diva2:677727
Note

QS 2013

Available from: 2013-12-10 Created: 2013-12-10 Last updated: 2013-12-10Bibliographically approved
In thesis
1. Synthesis and Characterization of Self-Assembling Low Molecular Weight Copolymers for Bioengineering Applications
Open this publication in new window or tab >>Synthesis and Characterization of Self-Assembling Low Molecular Weight Copolymers for Bioengineering Applications
2013 (English)Licentiate thesis, comprehensive summary (Other academic)
Abstract [en]

The constant need for improved biomedical materials and the interest in producing materials with similar properties to the extracellular matrix in different tissues has resulted in increasing interest in research on hydrogels. Over the last decade self-assembling copolymers have been of particular interest since they form hydrogels in response to external stimuli such as temperature. In this thesis, two self-assembling low molecular weight copolymers; poly(L-lactide-co-glycolide) grafted with poly(ethylene glycol) methyl ether (PLGA-g-MPEG) and poly(L-lysine-co-L-alanine) (poly(Lys-co-Ala)) were synthesized for possible bioengineering applications. Their chemical structure and composition was analysed by nuclear magnetic resonance spectroscopy (NMR) and matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). The results showed that low molecular weight PLGA-g-MPEG and poly(Lys-co-Ala) were successfully obtained.

PLGA-g-MPEG hydrogels were formed at 37°C, within 1 minute, at a pH between 6-7 and had a functional life of one month. The block cooligopeptides of L-lysine and L-alanine formed cubic, hexagonal and hollow crystals in low pH and irregularly shaped crystals in at pH 7, while plate-like crystals were formed at both pH 3 and 7 form the random cooligopeptides. Evaluation of the properties of the low molecular weight copolymers, such as pH, functional life and crystalline morphology, revealed that the chemical composition and solvent composition strongly affects their self-assembling properties.

These synthesized low molecular weight copolymers showed promise results for use as material in biomedical applications. Areas of potential use for these materials include bioengineered hierarchical scaffold material facilitating sequential release of growth factors, for example in bone tissue engineering, and as materials for encapsulated drug delivery.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. 44 p.
Series
Trita-CHE-Report, ISSN 1654-1081 ; 2013:46
Keyword
cooligomers, bioengineerng applications, polymer synthesis
National Category
Polymer Chemistry
Identifiers
urn:nbn:se:kth:diva-136843 (URN)978-91-7501-910-9 (ISBN)
Presentation
2013-12-12, K2, Teknikringen 28, KTH, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20131210

Available from: 2013-12-10 Created: 2013-12-09 Last updated: 2013-12-10Bibliographically approved

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Finne-Wistrand, Anna

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