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Magnetic microbubbles for multimodality imaging: the importance of the shell structure for low and high frequency mechanics
University Baureight.
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. (Contrast Enhanced Medical Imaging)
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging. Karolinska Institutet (KI), CLINTEC – Division of Medical Imaging and Technology. (Contrast Enhanced Medical Imaging)ORCID iD: 0000-0002-3699-396X
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Structural Biotechnology.ORCID iD: 0000-0002-9604-0511
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2013 (English)Conference paper, Abstract (Refereed)
Abstract [en]

There is a growing interest in magnetic microbubbles (MBs) for simultaneous enhanced ultrasound (US) and enhanced magnetic resonance imaging (MRI) to support well-established imaging procedures as well as new emerging diagnostic and therapeutic applications. However, the development of hybrid contrast agents is challenging, because their design needs to satisfy a variety of requirements such as a sufficient stability of the probe for the circulation within the cardiovascular system, the production of an adequate US echo signal and a reasonable reduced relaxation time of nearby located protons. The studied magnetic MBs consist of an air-filled core, which is encapsulated by a soft hydrogel-like shell composed of poly(vinyl alcohol) and superparamagnetic iron oxide nanoparticles (SPIONs)[1]. Two strategies were used to combine magnetic nanoparticles with the polymeric shell: SPIONs were either covalently attached to the shell surface via a post-chemical treatment or embedded physically inside the shell during the MBs’ synthesis. In particular, we were interested on the impact of the used SPIONs integration strategy on low and high frequency mechanics of the magnetic MBs. Therefore, we used a straightforward characterization of the MBs on the single particle level to correlate the synthesis with the MBs’ morphological properties and low frequency mechanics that were studied in quasi-static force measurements with atomic force microscopy. High frequency mechanics were investigated by exposure of an ensemble of MBs to an acoustic field. By further correlation of low and high frequency mechanics, we were able to bridge the gap between synthesis and the MBs macroscopic properties relevant for their application. The shown approach offers the possibility to sustainable design and optimize complex probes based on an improved understanding of structure/property relations.

Place, publisher, year, edition, pages
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Medical Laboratory and Measurements Technologies
URN: urn:nbn:se:kth:diva-137644OAI: diva2:679289
European symposium and exhibition on biomaterials and related areas, Euro BioMAT2013 23-24 Apr 2013 Weimar, Germany

QC 20140205

Available from: 2013-12-14 Created: 2013-12-14 Last updated: 2016-06-15Bibliographically approved

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Grishenkov, DmitryHärmark, Johan
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