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Achieving Micelle Control through Core Crystallinity
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.ORCID iD: 0000-0002-5850-8873
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymer Technology.
2013 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 14, no 11, 4150-4156 p.Article in journal (Refereed) Published
Abstract [en]

We have designed a pathway for controlling the critical micelle concentration and micelle size of polyester-based systems. This was achieved by creating an array of different copolymers with semicrystalline or amorphous hydrophobic blocks. The hydrophobic block was constructed through ring-opening polymerization of epsilon-caprolactone, L-lactide, and epsilon-decalactone, either as homopolymers or random copolymers, using PEG as both the initiator and the hydrophilic block. Micelles formed with amorphous cores exhibited considerably higher critical micelle concentrations than those with semicrystalline cores. Micelles with amorphous cores also became larger in size with an increased molecular weight of the hydrophobic bock, in contrast to micelles with semicrystalline cores, which displayed the opposite behavior. Hence, core crystallinity was found to be a potent tool for tailoring micelle properties and thereby facilitating the optimization of drug delivery systems. The introduction of PEG-P epsilon DL also proved to be a valuable asset in the tuning of micelle properties.

Place, publisher, year, edition, pages
2013. Vol. 14, no 11, 4150-4156 p.
Keyword [en]
Caprolactone, Crystallinities, Drug delivery system, Hydrophilic blocks, Hydrophobic blocks, Micelle size, Random copolymer, Semicrystallines
National Category
Polymer Technologies
Identifiers
URN: urn:nbn:se:kth:diva-137474DOI: 10.1021/bm401312jISI: 000326955900036Scopus ID: 2-s2.0-84887600073OAI: oai:DiVA.org:kth-137474DiVA: diva2:679641
Funder
EU, European Research Council, 246776
Note

QC 20131216

Available from: 2013-12-16 Created: 2013-12-13 Last updated: 2017-12-06Bibliographically approved

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Odelius, Karin

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