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HyperSPECT: a new instrument for high resolution single photon emission computed tomography
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
2013 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2013. , vi, 24 p.
Series
Trita-FYS, ISSN 0280-316X ; 2013:63
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-138301ISBN: 978-91-7501-946-8 (print)OAI: oai:DiVA.org:kth-138301DiVA: diva2:680767
Presentation
2013-12-13, Sal A2:1003, AlbaNova Universitetcentrum, Roslagstullsbacken 21, Stockholm, 13:00
Opponent
Supervisors
Note

QC 20131218

Available from: 2013-12-18 Created: 2013-12-18Bibliographically approved
List of papers
1. Feasibility Study for Photon Counting Detector for High Resolution Pre Clinical SPECT
Open this publication in new window or tab >>Feasibility Study for Photon Counting Detector for High Resolution Pre Clinical SPECT
2009 (English)In: 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), 2009, 3975-3979 p.Conference paper, Published paper (Refereed)
Abstract [en]

We plan to integrate a photon counting, large area, high spatial resolution, high efficiency detector in a system for pre-clinical SPECT. We are aiming for a high spatial resolution for the detector of around 20 mu m. The agent for radiolabelling is assumed to be I-125, with an emission peak at 27 keV, since it is readily available. The aim of this feasibility study was to optimize the scintillator and electronics. We consider a complementary metal-oxide-semiconductor (CMOS) circuit together with a columnar CsI scintillator. In our case CMOS is advantageous over CCD due to a more flexible readout and an opportunity for data processing and trigger logic at the pixel level. The position of the x-ray interaction in the scintillator can be estimated with high accuracy by fitting a two-dimensional Gaussian curve to the pixel hit-map. The goal of this study is to determine optimal scintillator thickness, pixel size, readout rate and the corresponding achievable spatial resolution. Results for a CA thickness of 600 mu m show a detection efficiency close to 90 % and a spatial resolution in the range of 20 mu m. Optimum pixel size for this application is between 40 - 60 mu m and as long as the readout speed exceeds 750 Hz the noise from the dark current will not be significant.

Series
IEEE NUCLEAR SCIENCE SYMPOSIUM - CONFERENCE RECORD, ISSN 1082-3654
Keyword
Complementary metal oxide semiconductors, Detection efficiency, Emission peaks, Feasibility studies, Gaussian curves, High efficiency, High resolution, High spatial resolution, Photon counting, Photon counting detectors, Pixel level, Pixel size, Pre-clinical, Radiolabelling, Readout rate, Spatial resolution, X-ray interaction, Charge coupled devices, Curve fitting, Data processing, Decision making, Detectors, Image resolution, Luminescence, Photons, Planning, Resource allocation, Scintillation, Scintillation counters
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-30734 (URN)10.1109/NSSMIC.2008.4774154 (DOI)000268656001281 ()2-s2.0-67649196785 (Scopus ID)978-1-4244-2714-7 (ISBN)
Conference
IEEE Nuclear Science Symposium/Medical Imaging Conference, Dresden, GERMANY, OCT 19-25, 2008
Note

QC 20110304

Available from: 2011-03-04 Created: 2011-03-04 Last updated: 2013-12-18Bibliographically approved
2. Simulation of HyperSPECT: a high-resolution small-animal system with in-line x-ray optics
Open this publication in new window or tab >>Simulation of HyperSPECT: a high-resolution small-animal system with in-line x-ray optics
2012 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 57, no 6, 1617-1629 p.Article in journal (Refereed) Published
Abstract [en]

SPECT has become an important tool in pre-clinical applications. Small-animal imaging systems based on the use of one or more pinhole collimators now reach sub-half-mm resolution but unfortunately suffer from a compromise between sensitivity and resolution due to the pinhole collimators. We propose a small-animal SPECT system based not on pinholes but on in-line x-ray optics, which is rare in medical imaging systems for nuclear medicine. The x-ray lenses are optimized for 27 keV for low-energy imaging with iodine-125. We believe that this new system, HyperSPECT, can simultaneously improve on sensitivity and resolution compared to today's state-of-the-art systems. A full three-dimensional simulation of the system has been performed including the prism-array lenses, pre-and post-collimators and scintillator-based detector. Images of capillary phantoms have been reconstructed using an iterative image reconstruction method. Sensitivity was uniformly 0.37% throughout the 1 cm diameter spherical field of view and rod sizes of around 100 mu m diameter were distinguishable in the images of simulated capillary phantoms. These results indicate an increase in resolution by a factor of 5 during a simultaneous increase in sensitivity by a factor of 2 compared to the current state-of-the-art small-animal SPECT systems.

National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:kth:diva-93382 (URN)10.1088/0031-9155/57/6/1617 (DOI)000301358000010 ()2-s2.0-84858062493 (Scopus ID)
Note

QC 20120416

Available from: 2012-04-16 Created: 2012-04-16 Last updated: 2017-12-07Bibliographically approved

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