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The prognostic value of mechanical left ventricular dyssynchrony in patients with acute coronary syndrome
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0002-5156-2535
KTH, School of Technology and Health (STH), Medical Engineering.
2013 (English)In: Cardiovascular Ultrasound, ISSN 1476-7120, E-ISSN 1476-7120, Vol. 11, no 1, 35- p.Article in journal (Refereed) Published
Abstract [en]

Background: Echocardiography is a well-established tool for risk stratification in patients with acute coronary syndrome (ACS). ACS has significant impact on LV dyssynchrony, and detrimental effects on systolic function and long term outcome. The aims of this study were to determine whether LV dyssynchrony carries any predictive information in an unselected ACS population and to evaluate if it has any incremental value to the information given from conventional echocardiographic measurements. Methods: The study included 227 consecutive ACS patients. Primary endpoint was the composite of death, new MI, or rehospitalisation due to heart failure. Dyssynchrony was measured as intersegmental variation of time to peak strain, the post systolic index (PSI) and myocardial performance index (MPI) with the standard deviation and difference between lowest and highest value (delta) expressing the amount of dyssynchrony. Septal-lateral delay was also tested. All dyssynchrony parameters were compared with Ejection fraction (EF). Results: The median follow up time was 53 months. 85 patients reached the combined endpoint. Patients with and without a subsequent combined endpoint differed significantly regarding calculated SD: s and delta-value for PSI, time to peak 2D-strain and MPI but not regarding septal-lateral delay. In ROC-analysis none of the dyssynchrony parameters had larger AUC than EF. When adjusting for traditional risk factors none of the dyssynchrony parameters remained associated with outcome, whereas EF still did. Conclusion: LV dyssynchrony seem to have significant prognostic information in patient with acute coronary syndrome but in comparison to conventional parameters such as EF there is no incremental value of this information.

Place, publisher, year, edition, pages
2013. Vol. 11, no 1, 35- p.
Keyword [en]
Acute coronary syndrome, Prognostic parameters, Tissue doppler, Dyssynchrony
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:kth:diva-138375DOI: 10.1186/1476-7120-11-35ISI: 000327521000001Scopus ID: 2-s2.0-84885342523OAI: oai:DiVA.org:kth-138375DiVA: diva2:681502
Note

QC 20131220

Available from: 2013-12-20 Created: 2013-12-19 Last updated: 2017-12-06Bibliographically approved

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