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Calcium oscillations triggered by cardiotonic steroids
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.ORCID iD: 0000-0003-0578-4003
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2013 (English)In: The FEBS Journal, ISSN 1742-464X, E-ISSN 1742-4658, Vol. 280, no 21, 5450-5455 p.Article, review/survey (Refereed) Published
Abstract [en]

Na+, K+-ATPase (NKA) is well known for its function as an ion pump. Studies during the last decade have revealed an additional role for NKA as a signal transducer. In this brief review, we describe how cardiotonic steroids, which are highly specific NKA ligands, trigger slow Ca2+ oscillations by promoting the interaction between NKA and the inositol trisphosphate receptor, and how this Ca2+ signal activates the NF-B subunit p65 and increases the expression of the antiapoptotic factor Bcl-xL. The potential tissue-protective effects of this signal are discussed.

Place, publisher, year, edition, pages
2013. Vol. 280, no 21, 5450-5455 p.
Keyword [en]
apoptosis, Ca2+ signaling, cardiotonic steroids, inositol trisphosphate receptor, intracellular Ca2+ oscillations, Na+-K+-ATPase, NF-B, organ development, ouabain, Src kinase
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-139521DOI: 10.1111/febs.12448ISI: 000328622200018ScopusID: 2-s2.0-84886096465OAI: diva2:687702
Swedish Research Council

QC 20140115

Available from: 2014-01-15 Created: 2014-01-14 Last updated: 2014-01-20Bibliographically approved

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Khodus, GeorgiyBrismar, Hjalmar
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