Calcium oscillations triggered by cardiotonic steroids
2013 (English)In: The FEBS Journal, ISSN 1742-464X, E-ISSN 1742-4658, Vol. 280, no 21, 5450-5455 p.Article, review/survey (Refereed) Published
Na+, K+-ATPase (NKA) is well known for its function as an ion pump. Studies during the last decade have revealed an additional role for NKA as a signal transducer. In this brief review, we describe how cardiotonic steroids, which are highly specific NKA ligands, trigger slow Ca2+ oscillations by promoting the interaction between NKA and the inositol trisphosphate receptor, and how this Ca2+ signal activates the NF-B subunit p65 and increases the expression of the antiapoptotic factor Bcl-xL. The potential tissue-protective effects of this signal are discussed.
Place, publisher, year, edition, pages
2013. Vol. 280, no 21, 5450-5455 p.
apoptosis, Ca2+ signaling, cardiotonic steroids, inositol trisphosphate receptor, intracellular Ca2+ oscillations, Na+-K+-ATPase, NF-B, organ development, ouabain, Src kinase
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:kth:diva-139521DOI: 10.1111/febs.12448ISI: 000328622200018ScopusID: 2-s2.0-84886096465OAI: oai:DiVA.org:kth-139521DiVA: diva2:687702
FunderSwedish Research Council
QC 201401152014-01-152014-01-142014-01-20Bibliographically approved