Change search
ReferencesLink to record
Permanent link

Direct link
Advances in metabolic pathway and strain engineering paving the way for sustainable production of chemical building blocks
KTH, Centres, Science for Life Laboratory, SciLifeLab. Novo Nordisk Foundation Center for Biosustainability.
2013 (English)In: Current Opinion in Biotechnology, ISSN 0958-1669, E-ISSN 1879-0429, Vol. 24, no 6, 965-972 p.Article, review/survey (Refereed) Published
Abstract [en]

Bio-based production of chemical building blocks from renewable resources is an attractive alternative to petroleum-based platform chemicals. Metabolic pathway and strain engineering is the key element in constructing robust microbial chemical factories within the constraints of cost effective production. Here we discuss how the development of computational algorithms, novel modules and methods, omics-based techniques combined with modeling refinement are enabling reduction in development time and thus advance the field of industrial biotechnology. We further discuss how recent technological developments contribute to the development of novel cell factories for the production of the building block chemicals: adipic acid, succinic acid and 3-hydroxypropionic acid.

Place, publisher, year, edition, pages
2013. Vol. 24, no 6, 965-972 p.
Keyword [en]
3-Hydroxypropionic acid, Chemical building blocks, Computational algorithm, Cost-effective production, Industrial biotechnology, Strain engineering, Sustainable production, Technological development, Metabolic engineering, Metabolism, Indicators (chemical)
National Category
Chemical Engineering
URN: urn:nbn:se:kth:diva-139879DOI: 10.1016/j.copbio.2013.03.008ISI: 000328806200002ScopusID: 2-s2.0-84887618970OAI: diva2:688790
VinnovaKnut and Alice Wallenberg FoundationEU, European Research Council, 247013Science for Life Laboratory - a national resource center for high-throughput molecular bioscience

QC 20140117

Available from: 2014-01-17 Created: 2014-01-15 Last updated: 2014-01-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Nielsen, Jens
By organisation
Science for Life Laboratory, SciLifeLab
In the same journal
Current Opinion in Biotechnology
Chemical Engineering

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 42 hits
ReferencesLink to record
Permanent link

Direct link