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Technical Requirements for Na18F PET Bone Imaging of Patients Being Treated Using a Taylor Spatial Frame.
Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden .
Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden .
Department of Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden .
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden .
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2014 (English)In: Journal of nuclear medicine technology, ISSN 1535-5675Article in journal (Refereed) Published
Abstract [en]

Diagnosis of new bone growth in patients with compound tibia fractures or deformities treated using a Taylor spatial frame is difficult with conventional radiography because the frame obstructs the images and creates artifacts. The use of Na(18)F PET studies may help to eliminate this difficulty.

METHODS: Patients were positioned on the pallet of a clinical PET/CT scanner and made as comfortable as possible with their legs immobilized. One bed position covering the site of the fracture, including the Taylor spatial frame, was chosen for the study. A topogram was performed, as well as diagnostic and attenuation correction CT. The patients were given 2 MBq of Na(18)F per kilogram of body weight. A 45-min list-mode acquisition was performed starting at the time of injection, followed by a 5-min static acquisition 60 min after injection. The patients were examined 6 wk after the Taylor spatial frame had been applied and again at 3 mo to assess new bone growth.

RESULTS: A list-mode reconstruction sequence of 1 × 1,800 and 1 × 2,700 s, as well as the 5-min static scan, allowed visualization of regional bone turnover.

CONCLUSION: With Na(18)F PET/CT, it was possible to confirm regional bone turnover as a means of visualizing bone remodeling without the interference of artifacts from the Taylor spatial frame. Furthermore, dynamic list-mode acquisition allowed different sequences to be performed, enabling, for example, visualization of tracer transport from blood to the fracture site.

Place, publisher, year, edition, pages
2014.
Keyword [en]
Na18F, PET/CT, Taylor spatial frame, bone imaging
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-140510DOI: 10.2967/jnmt.113.133082PubMedID: 24436472Scopus ID: 2-s2.0-84897483981OAI: oai:DiVA.org:kth-140510DiVA: diva2:690825
Note

QC 20150629

Available from: 2014-01-24 Created: 2014-01-24 Last updated: 2015-06-29Bibliographically approved

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Maguire Jr., Gerald Q.Noz, Marilyn E.

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