Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Analysis of plasma from prostate cancer patients links decreased carnosine dipeptidase 1 levels to lymph node metastasis
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-7674-2014
Show others and affiliations
2014 (English)In: Translational Proteomics, ISSN 2212-9634, Vol. 2, no 1, 14-24 p.Article in journal (Refereed) Published
Abstract [en]

There is a need for a better differentiation of aggressive tumors in prostate cancer to design a tailored treatment for each patient, preferably by a minimally invasive analysis of blood samples. In a previous study, we discovered a decrease of plasma levels of carnosine dipeptidase 1 (CNDP1) in association with aggressive prostate cancer. Now this relation has been investigated and characterized further by generating several new antibodies for extended analysis of CNDP1 in plasma. Multi-antibody sandwich assays were developed and applied to 1214 samples from two Swedish cohorts that confirmed decreased levels of CNDP1 in plasma from patients with advanced disease. Therein, data from CNDP1 assays allowed a better differentiation between tumor N stages than clinical tPSA, but did not when classifying T or M stages. Further investigations can now elucidate mechanisms behind decreasing levels of CNDP1 in plasma and primary in regards to lymph node metastasis.

Place, publisher, year, edition, pages
2014. Vol. 2, no 1, 14-24 p.
Keyword [en]
Carnosine dipeptidase 1, Plasma biomarker, Prostate cancer, Sandwich immunoassay, Suspension bead array
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-140795DOI: 10.1016/j.trprot.2013.12.001Scopus ID: 2-s2.0-84891341787OAI: oai:DiVA.org:kth-140795DiVA: diva2:693090
Note

QC 20140203

Available from: 2014-02-03 Created: 2014-01-31 Last updated: 2014-02-03Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Uhlén, MathiasSchwenk, Jochen M.

Search in DiVA

By author/editor
Qundos, UlrikaFredolini, ClaudiaUhlén, MathiasNilsson, PeterSchwenk, Jochen M.
By organisation
Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLab
Medical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 54 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf