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Liposome and protein based stealth nanoparticles
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2013 (English)In: Faraday discussions (Online), ISSN 1359-6640, E-ISSN 1364-5498, Vol. 166, 417-429 p.Article in journal (Refereed) Published
Abstract [en]

Liposomes and protein based nanoparticles were tuned with different polymers and glycolipids to improve stealth and thus decrease their clearance by macrophages. Liposomes were coated with polyethylene glycol (PEG) and brain-tissue-derived monosialoganglioside (GM1). Bovine serum albumin (BSA) nanoparticles were produced incorporating a PEGylated surfactant (PEG-surfactant). All obtained nanoparticles were monodisperse, with sizes ranging from 80 to 120 nm, with a zeta-potential close to zero. The presented stealth strategies lead to a decrease of internalization levels by macrophages. These surface modified nanoparticles could be used for production of new drug delivery nanosystems for systemic administration (e.g. intravenous application).

Place, publisher, year, edition, pages
2013. Vol. 166, 417-429 p.
Keyword [en]
Drug-Delivery Systems, Poly(Ethylene Glycol), Circulation Time, In-Vivo, Cancer, Opsonization, Pharmacokinetics, Microspheres, Optimization, Formulations
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Identifiers
URN: urn:nbn:se:kth:diva-141099DOI: 10.1039/c3fd00057eISI: 000329305100026PubMedID: 24611291Scopus ID: 2-s2.0-84887481690OAI: oai:DiVA.org:kth-141099DiVA: diva2:694656
Funder
EU, FP7, Seventh Framework Programme, NMP4-LA-2009-228827 NANOFOL
Note

QC 20150623

Available from: 2014-02-07 Created: 2014-02-07 Last updated: 2017-12-06Bibliographically approved

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Härmark, JohanHebert, Hans

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