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Dynamic heterogeneity controls diffusion and viscosity near biological interfaces
KTH, School of Engineering Sciences (SCI), Theoretical Physics, Theoretical & Computational Biophysics. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Engineering Sciences (SCI), Theoretical Physics, Theoretical & Computational Biophysics. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0002-2734-2794
2014 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 5, 3034- p.Article in journal (Refereed) Published
Abstract [en]

At a nanometre scale, the behaviour of biological fluids is largely governed by interfacial physical chemistry. This may manifest as slowed or anomalous diffusion. Here we describe how measures developed for studying glassy systems allow quantitative measurement of interfacial effects on water dynamics, showing that correlated motions of particles near a surface result in a viscosity greater than anticipated from individual particle motions. This effect arises as a fundamental consequence of spatial heterogeneity on nanometre length scales and applies to any fluid near any surface. Increased interfacial viscosity also causes the classic finding that large solutes such as proteins diffuse much more slowly than predicted in bulk water. This has previously been treated via an empirical correction to the solute size: the hydrodynamic radius. Using measurements of quantities from theories of glass dynamics, we can now calculate diffusion constants from molecular details alone, eliminating the empirical correction factor.

Place, publisher, year, edition, pages
2014. Vol. 5, 3034- p.
Keyword [en]
Anomalous Diffusion, Molecular Simulation, Hydration Dynamics, Water Dynamics, Liquid Water, Random-Walks, Protein, Surfaces, Time, Confinement
National Category
Biophysics
Identifiers
URN: urn:nbn:se:kth:diva-142893DOI: 10.1038/ncomms4034ISI: 000331083800017OAI: oai:DiVA.org:kth-142893DiVA: diva2:705059
Funder
EU, European Research CouncilSwedish Research CouncilSwedish Foundation for Strategic Research Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20140314

Available from: 2014-03-14 Created: 2014-03-13 Last updated: 2017-12-05Bibliographically approved

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Lindahl, Erik

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