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Development of a coordinated allo T cell and auto B cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation
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2014 (English)In: Haematologica, ISSN 0390-6078, E-ISSN 1592-8721, Vol. 99, no 2, p. 365-369Article in journal (Refereed) Published
Abstract [en]

It is well known that allo-reactive T cells play a crucial role in graft-versus-leukemia and graft-versus-host disease after allogeneic hematopoietic stem cell transplantation (alloSCT). Allo-reactive CD4+ T cells can mediate direct cytolysis, but may also stimulate production of IgG antibodies as helper cells. Immune complexes may subsequently be processed and presented by professional antigen presenting cells and stimulate induction of specific CD8+ T cells. As such, proteins targeted in coordinated T- and B-cell responses may represent a class of immunodominant antigens in clinical responses after alloSCT. We previously identified LB-PTK2B-1T as HLA class II restricted polymorphic antigen in a patient treated with donor lymphocyte infusion for relapsed chronic myeloid leukemia after HLA-matched alloSCT. Since PTK2B has also been described as antibody target, we here investigated whether a coordinated T- and B-cell response against PTK2B was induced. Patient serum before and after alloSCT and donor lymphocyte infusion (DLI) was screened for antibodies, and we indeed observed development of a humoral immune response against PTK2B. Antibodies against PTK2B were only found after DLI and, in contrast to the CD4+ T cells, recognized a monomorphic region of the protein. To our knowledge, this is the first description of a coordinated allo-reactive CD4+ T-cell and auto-reactive antibody response against an autosomal antigen.

Place, publisher, year, edition, pages
2014. Vol. 99, no 2, p. 365-369
Keywords [en]
Histocompatibility Antigen Dby, Chronic Myelogenous Leukemia, Cross-Presentation, Antibody-Response, Dendritic Cells, Myeloma, Identification, Lymphocytes, Remission, Expansion
National Category
Hematology
Identifiers
URN: urn:nbn:se:kth:diva-143001DOI: 10.3324/haematol.2013.086652ISI: 000336253900031Scopus ID: 2-s2.0-84896737137OAI: oai:DiVA.org:kth-143001DiVA, id: diva2:705144
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscience
Note

QC 20140314

Available from: 2014-03-14 Created: 2014-03-14 Last updated: 2017-12-05Bibliographically approved

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Ayoglu, BurcuSchwenk, Jochen M.

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