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Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-0198-7137
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-3014-5502
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2014 (English)In: Molecular & Cellular Proteomics, ISSN 1535-9476, E-ISSN 1535-9484, Vol. 13, no 2, 397-406 p.Article in journal (Refereed) Published
Abstract [en]

Global classification of the human proteins with regards to spatial expression patterns across organs and tissues is important for studies of human biology and disease. Here, we used a quantitative transcriptomics analysis (RNA-Seq) to classify the tissue-specific expression of genes across a representative set of all major human organs and tissues and combined this analysis with antibody- based profiling of the same tissues. To present the data, we launch a new version of the Human Protein Atlas that integrates RNA and protein expression data corresponding to 80% of the human protein-coding genes with access to the primary data for both the RNA and the protein analysis on an individual gene level. We present a classification of all human protein-coding genes with regards to tissue-specificity and spatial expression pattern. The integrative human expression map can be used as a starting point to explore the molecular constituents of the human body.

Place, publisher, year, edition, pages
2014. Vol. 13, no 2, 397-406 p.
Keyword [en]
article, gene expression, human, human tissue, immunohistochemistry, priority journal, protein analysis, protein expression, proteomics, spermatogenesis, transcriptomics
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-142992DOI: 10.1074/mcp.M113.035600ISI: 000331369000002PubMedID: 24309898Scopus ID: 2-s2.0-84893276590OAI: oai:DiVA.org:kth-142992DiVA: diva2:705159
Funder
Science for Life Laboratory - a national resource center for high-throughput molecular bioscienceKnut and Alice Wallenberg FoundationEU, FP7, Seventh Framework Programme, HEALTH-F4-2008-201648/PROSPECTS
Note

QC 20140314

Available from: 2014-03-14 Created: 2014-03-14 Last updated: 2017-12-05Bibliographically approved

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Fagerberg, LinnOksvold, PerSzigyarto, Cristina Al-KhaliliSkogs, MarieSchwenk, Jochen M.Uhlén, Mathias

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Fagerberg, LinnHallström, Björn M.Oksvold, PerOdeberg, JacobHabuka, MasatoSzigyarto, Cristina Al-KhaliliSkogs, MarieTegel, HannaNilsson, PeterSchwenk, Jochen M.Danielsson, FridaSivertsson, ÅsaVon Feilitzen, KalleForsberg, MattiasZwahlen, MartinNielsen, JensUhlén, Mathias
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Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLabGene Technology
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