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Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?
Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden .
KTH, School of Information and Communication Technology (ICT), Communication Systems, CoS, Radio Systems Laboratory (RS Lab).ORCID iD: 0000-0002-6066-746X
Karolinska Institute. (Department of Molecular Medicine and Surgery, Section of Orthopaedics and Sport Medicine)
Department of Medical Physics, Karolinska University Hospital, Stockholm, Sweden.ORCID iD: 0000-0002-5870-2975
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2014 (English)In: Scientific World Journal, ISSN 1537-744X, E-ISSN 1537-744X, Vol. 2014, 1-9 p.Article in journal (Refereed) Published
Abstract [en]

Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent. Each patient was examined by (NaF)-F-18 PET/CT twice, at approximately six weeks and three months after the operation. A validated software tool was used for the following processing steps. The first and second CT volumes were aligned in 3D and the respective PET volumes were aligned accordingly. In the first PET volume spherical volumes of interest (VOIs) were delineated for the crural fracture and normal bone and transferred to the second PET volume for SUVmax evaluation. This method potentially provides clinical insight into questions such as, when has the bone remodeling progressed well enough to safely remove the TSF? and when is intervention required, in a timelier manner than current methods? For example, in two patients who completed treatment, the SUVmax between the first and second PET/CT examination decreased by 42% and 13%, respectively. Further studies in a larger patient population are needed to verify these preliminary results by correlating regional (NaF)-F-18 PET measurements to clinical and radiological findings.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2014. Vol. 2014, 1-9 p.
Keyword [en]
Na18F, PET/CT, Bone Remodeling, Taylor Spatial Frame
National Category
Radiology, Nuclear Medicine and Medical Imaging
URN: urn:nbn:se:kth:diva-143408DOI: 10.1155/2014/249326ISI: 000333602000001ScopusID: 2-s2.0-84897484026OAI: diva2:706514

QC 20140505. QC 20160222

Available from: 2014-03-20 Created: 2014-03-20 Last updated: 2016-02-22Bibliographically approved

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Maguire Jr., Gerald Q.Jonsson, CathrineJacobsson, HansNoz, Marilyn E.Zeleznik, Michael P.Weidenhielm, Lars
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Radio Systems Laboratory (RS Lab)
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Scientific World Journal
Radiology, Nuclear Medicine and Medical Imaging

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