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A simplied Medium SpinyNeuron-model with retained intrinsic characteristics and plateau properties
KTH, School of Computer Science and Communication (CSC).
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesisAlternative title
En morfologiskt reducerad modell av en medium spiny neuron med bibehallna intrinsiska- och plataegenskaper (Swedish)
Abstract [en]

This master thesis studies how a morphological reduction aects theperformance of a biophysically detailed model of a medium spiny neuron. Themorphological reduction is done using a MATLAB toolbox developed forautomatic 3-dimensional morphological reduction. Two versions of the toolboxare developed in which dierent criteria are used during the merge. Theevaluation of the two toolboxes shows that keeping the absolute distance to thesoma of the branching points and the surface area of the dendrites gives a moreaccurate result than if these criteria are not used. These criteria are implementedin Toolbox 2. In total 8 models with dierent maximal compartment length arethen constructed using Toolbox 2. The number of compartments in the resultingmodels range from 1/2 to 1/10 of the compartments in the original model. Furtherthe performance of the reduced models are evaluated against the original model.The results of this evaluation shows that an increasing compartment length givesa decrease in consistency with the response of the original model. However theresponse of all models are largely similar to the original model.

Abstract [sv]

I detta examensarbete studeras hur en biofysikt detaljerad modell av en mediumspiny neuron (direkt oversatt "medellang taggig neuron") paverkas av en reduceringav dess strukturella komplexitet. Denna strukturella reduktion gar till saatt fragmenten som formar modellen slas samman och bildar nya fragment. Denya fragmenten far da en langd motsvarande summan av de sammanslagna fragmentenslangd. For att underlatta den strukturella reduktionen utvecklas ocksa enverktygslada till MATLAB. Verktygsladan ar byggd for att automatiskt reduceraden 3-dimensionella strukturen av en modell baserat pa vissa kriterier. Tva versionerav vertygsladan utvecklas i vilka kriterierna som anvands vid reduktionenskiljer sig fran varandra. Utvarderingen av de bada versionerna visar att omavstandet mellan cellkarnan och de dendritiska forgreningspunkterna samt dentotala dendritiska arean ar konstant sa uppnas ett battre resultat an om dessakriterier inte uppfylls. Dessa kriterier implementeras i den andra versionen avvertygsladan, Toolbox 2. Med hjalp av Toolbox 2 tillverkas sedan 8 reducerademodeller som alla har reducerad struktur men olika maximal langd pa fragmenten.De reducerade Modellerna ar uppbyggda av mellan 1/2 och 1/10 av antalet fragmenti den ursprungliga modellen. De reducerade modellerna jamfors sedan medden ursprungliga modellen. Resultatet av jamforelsen visar att med okad fragmentlangd kommer ocksa en gradvis storre avvikelse fran den ursprungliga modellen.Detta till trots gav alla reducerade modeller en overraskande bra respons ialla test de utsattes for.

Place, publisher, year, edition, pages
2013.
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:kth:diva-143499OAI: oai:DiVA.org:kth-143499DiVA: diva2:706744
Educational program
Master of Science in Engineering - Biotechnology
Supervisors
Examiners
Available from: 2015-04-20 Created: 2014-03-21 Last updated: 2015-04-20Bibliographically approved

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