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Whole body and regional body composition changes following 10-day hypoxic confinement and unloading-inactivity
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology.
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2014 (English)In: Applied Physiology, Nutrition and Metabolism, ISSN 1715-5312, Vol. 39, no 3, 386-395 p.Article in journal (Refereed) Published
Abstract [en]

Future planetary habitats will expose inhabitants to both reduced gravity and hypoxia. This study investigated the effects of short-term unloading and normobaric hypoxia on whole body and regional body composition (BC). Eleven healthy, recreationally active, male participants with a mean (SD) age of 24 (2) years and body mass index of 22.4 (3.2) kg.m(-2) completed the following 3 10-day campaigns in a randomised, cross-over designed protocol: (i) hypoxic ambulatory confinement (HAMB; FIO2 = 0.147 (0.008); PIO2 = 93.8 (0.9) mm Hg), (ii) hypoxic bed rest (HBR; FIO2 = 0.147 (0.008); PIO2 = 93.8 (0.9) mm Hg), and (iii) normoxic bed rest (NBR; FIO2 = 0.209; PIO2 = 133.5 (0.7) mmHg). Nutritional requirements were individually precalculated and the actual intake was monitored throughout the study protocol. Body mass, whole body, and regional BC were assessed before and after the campaigns using dual-energy X-ray absorptiometry. The calculated daily targeted energy intake values were 2071 (170) kcal for HBR and NBR and 2417 (200) kcal for HAMB. In both HBR and NBR campaigns the actual energy intake was within the targeted level, whereas in the HAMB the intake was lower than targeted (-8%, p < 0.05). Body mass significantly decreased in all 3 campaigns (-2.1%, -2.8%, and -2.0% for HAMB, HBR, and NBR, respectively; p < 0.05), secondary to a significant decrease in lean mass (-3.8%, -3.8%, -4.3% for HAMB, HBR, and NBR, respectively; p < 0.05) along with a slight, albeit not significant, increase in fat mass. The same trend was observed in the regional BC regardless of the region and the campaign. These results demonstrate that, hypoxia per se, does not seem to alter whole body and regional BC during short-term bed rest.

Place, publisher, year, edition, pages
2014. Vol. 39, no 3, 386-395 p.
Keyword [en]
simulated microgravity, simulated altitude, fat mass, lean mass, energy intake, hypoxemia
National Category
Nutrition and Dietetics Physiology Sport and Fitness Sciences
URN: urn:nbn:se:kth:diva-143687DOI: 10.1139/apnm-2013-0278ISI: 000331946300017ScopusID: 2-s2.0-84894104531OAI: diva2:708898

QC 20140331

Available from: 2014-03-31 Created: 2014-03-27 Last updated: 2014-03-31Bibliographically approved

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