Change search
ReferencesLink to record
Permanent link

Direct link
Uniaxial tensile testing approaches for characterisation of atherosclerotic plaques
Show others and affiliations
2014 (English)In: Journal of Biomechanics, ISSN 0021-9290, E-ISSN 1873-2380, Vol. 47, no 4, 793-804 p.Article in journal (Refereed) Published
Abstract [en]

The pathological changes associated with the development of atherosclerotic plaques within arterial vessels result in significant alterations to the mechanical properties of the diseased arterial wall. There are several methods available to characterise the mechanical behaviour of atherosclerotic plaque tissue, and it is the aim of this paper to review the use of uniaxial mechanical testing. In the case of atherosclerotic plaques, there are nine studies that employ uniaxial testing to characterise mechanical behaviour. A primary concern regarding this limited cohort of published studies is the wide range of testing techniques that are employed. These differing techniques have resulted in a large variance in the reported data making comparison of the mechanical behaviour of plaques from different vasculatures, and even the same vasculature, difficult and sometimes impossible. In order to address this issue, this paper proposes a more standardised protocol for uniaxial testing of diseased arterial tissue that allows for better comparisons and firmer conclusions to be drawn between studies. To develop such a protocol, this paper reviews the acquisition and storage of the tissue, the testing approaches, the post-processing techniques and the stress-strain measures employed by each of the nine studies. Future trends are also outlined to establish the role that uniaxial testing can play in the future of arterial plaque mechanical characterisation.

Place, publisher, year, edition, pages
2014. Vol. 47, no 4, 793-804 p.
Keyword [en]
Atherosclerotic plaque, Uniaxial test, Artery, Biomechanics
National Category
URN: urn:nbn:se:kth:diva-145093DOI: 10.1016/j.jbiomech.2014.01.017ISI: 000334003700005ScopusID: 2-s2.0-84894649638OAI: diva2:716416

QC 20140509

Available from: 2014-05-09 Created: 2014-05-08 Last updated: 2014-05-09Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Holzapfel, Gerhard A.
By organisation
Solid Mechanics (Dept.)
In the same journal
Journal of Biomechanics

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link