Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis
2014 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 356, no 5, 987-992 p.Article in journal (Refereed) Published
Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.
Place, publisher, year, edition, pages
2014. Vol. 356, no 5, 987-992 p.
adaptive features, biotransformations, chiral resolution, domino reactions, dynamic chemistry, enzymes, lipase, stereochemistry
IdentifiersURN: urn:nbn:se:kth:diva-145281DOI: 10.1002/adsc.201301033ISI: 000333196000012ScopusID: 2-s2.0-84897025576OAI: oai:DiVA.org:kth-145281DiVA: diva2:717408
FunderSwedish Research Council
QC 201405152014-05-152014-05-152014-05-15Bibliographically approved