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A fiber optic system for detection and collection of micrometer-size particles
KTH, School of Engineering Sciences (SCI), Applied Physics, Quantum Electronics and Quantum Optics, QEO. Acreo Swedish ICT AB, Dept Fiber Opt, Sweden.
KTH, School of Engineering Sciences (SCI), Applied Physics. Acreo Swedish ICT AB, Dept Fiber Opt, Sweden.
KTH, School of Engineering Sciences (SCI), Applied Physics, Quantum Electronics and Quantum Optics, QEO.
KTH, School of Engineering Sciences (SCI), Applied Physics, Laser Physics.ORCID iD: 0000-0001-7688-1367
Show others and affiliations
2014 (English)In: Optics Express, ISSN 1094-4087, E-ISSN 1094-4087, Vol. 22, no 18, 21480-21487 p.Article in journal (Refereed) Published
Abstract [en]

An optical fiber containing longitudinal holes adjacent to the core has been used to detect and collect fluorescent particles from a solution. Excitation light was launched through the fiber and fluorescence signal was guided back to a detector system. As a proof of principle, green and red fluorescent polystyrene beads were detected and selectively collected from a water solution containing a mixture of red and green fluorescent beads.

Place, publisher, year, edition, pages
2014. Vol. 22, no 18, 21480-21487 p.
National Category
Other Physics Topics
Identifiers
URN: urn:nbn:se:kth:diva-145318DOI: 10.1364/OE.22.021480ISI: 000341428000033Scopus ID: 2-s2.0-84907284431OAI: oai:DiVA.org:kth-145318DiVA: diva2:717558
Note

Updated from submitted to published.

QC 20141003

Available from: 2014-05-15 Created: 2014-05-15 Last updated: 2017-12-05Bibliographically approved
In thesis
1. Increased Functionality of Optical Fibers for Life-Science Applications
Open this publication in new window or tab >>Increased Functionality of Optical Fibers for Life-Science Applications
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The objective of this thesis work is to increase the functionality of optical fibers for possible applications in life-sciences. Optical fibers are a promising technology for use in biology and medicine. They are low-costwaveguides, flexible and have a small cross-section. They can guide high-power light with low loss in a micrometer core-size. These features make fibers attractive for minimally-invasive,in-vivostudies. The backwards guidance of the optical signal allows for real-time monitoring of the distance to the scattering targets and to study the environment through Raman scattering and fluorescence excitation. The longitudinal holes introduced in the fibers can be used,for instance,for delivery of medicine to a specific regionof a body. They could even be used for the extractionof species considered interesting for further analysis, for example, studyingcells that may be cancer-related.

This thesis deals with four main topics. First, a demonstration is presented of the combination of high-power light guidance for ablation, low-power light reflectometry for positioning, and for liquid retrieval in a single fiber. It was found that in order to exploit the microfluidic possibilities available in optical fibers with holes, one needs to be able to combine fluids and light in a fiber without hindering the low-loss light guidance and the fluid flow. Secondly, one should also be able to couple light into the liquids and backout again. This is the subject of another paper in the present thesis. It was also observed that laser excitation through a fiber for the collection of a low-intensity fluorescence signal was often affected by the luminescence noise createdby the primary-coating of the fiber. This problem makes it difficult to measure low light-levels, for example, from single-cells. Athirdpaper in this thesis then describes a novel approach to reduce the luminescence from the polymer coating of the fiber, with the use of a nanometer-thick carbon layer on the cladding surface. Finally, exploiting some of the results described earlier, an optical fiber with longitudinal holes is used for the excitation, identification and for the collection of particles considered being of interest. The excitation light is guided in the fiber, the identification is performed by choosing the fluorescent particles with the appropriate wavelength, and, when a particle of interest is sufficiently near the fiber-tip, the suction system is activated for collection of the particle with good specificity.

It is believed that the work described in this thesis could open the doors for applications in life-sciences and the future use of optical fibers for in-vivo studies.

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2014. xii, 63 p.
Series
TRITA-FYS, ISSN 0280-316X ; 2014:15
Keyword
Fiberoptics, microstructured fiber, fiber - based optofluidics, laser ablation, microfluidics, reflectometry, fluorescence detection, fiber - based spectroscopy
National Category
Other Physics Topics
Research subject
Physics
Identifiers
urn:nbn:se:kth:diva-145319 (URN)978-91-7595-122-5 (ISBN)
Public defence
2014-05-21, sal FB5, AlbaNova Universitetscentrum, Roslagstullsbacken 21, Stockholm, 10:00 (English)
Opponent
Supervisors
Note

QC 20140516

Available from: 2014-05-16 Created: 2014-05-15 Last updated: 2014-05-16Bibliographically approved
2. Advanced all-fiber optofluidic devices
Open this publication in new window or tab >>Advanced all-fiber optofluidic devices
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Significant technological advances of the last years have been possible by developments in Optofluidics, which is a field that deals with the integration of optics and microfluidics into single devices.

The work described in this thesis is based on five scientific publications related to the use of fiber optic technology to build integrated optofluidic devices. The first three publications are within the field of life-science and point towards in-vivo and point-of-care applications, whereas the last two publications cover the study and the use of plasmonic nanoparticles for electrical modulation of light.

Aiming at developing useful tools for in-vivo biological applications, the first publication consists of designing and testing a functional optical fiber for real-time monitoring and selective collection of fluorescent microparticles. This probe relies on a microstructured optical fiber with a hole along its cladding, which is used to selectively aspirate individual particles of interest once their fluorescence signal is detected. On the same line of research, the second publication contemplates the fabrication of a fiber probe that traps single microparticles and allows for remote detection of their optical properties. This probe is also based on a microstructured fiber that enables particle trapping by fluidic forces. The third publication addresses the development of an all-fiber miniaturized flow cytometer for point-of-care applications. This system can analyze, with excellent accuracy and sensitivity, up to 2500 cells per second by measuring their fluorescence and scattering signal. A novel microfluidic technique, called Elasto-inertial microfluidics, is employed for aligning the cells into a single-stream to optimize detection and throughput.

The fourth publication involves the experimental and theoretical study of the electrical-induced alignment of plasmonic gold nanorods in suspension and its applicability to control light transmission. This study is done by using an all-fiber optofluidic device, based on a liquid-core fiber, which facilitates the interaction of light, electric fields, and liquid suspensions. Results show that nanorods can be aligned in microseconds, providing a much better performance than liquid-crystal devices. Finally, the fifth publication consists of an upgrade of the previous device by integrating four electrodes in the cladding of the liquid-core fiber. This improvement enables nanosecond response time and the possibility of digitally switching nanorods between two orthogonal aligned states, overcoming the limitation of slow thermal relaxation.

The work presented here shows that optofluidics based on optical fibers is a robust and convenient platform, as well as a promising direction for the developing of novel instruments in fields such as life-science, non-linear optics, plasmonic, and sensing.

Place, publisher, year, edition, pages
KTH Royal Institute of Technology, 2017. 68 p.
Series
TRITA-FYS, ISSN 0280-316X ; 2017:65
Keyword
Fiber optics, functional fiber probes, optofluidics, microfluidics, plasmonic, all-fiber technology, instrumentation for life-sciences.
National Category
Medical Engineering Physical Sciences Medical Laboratory and Measurements Technologies
Research subject
Physics
Identifiers
urn:nbn:se:kth:diva-215938 (URN)978-91-7729-572-3 (ISBN)
Public defence
2017-11-14, FB42, Albanova, Roslagstullsbacken 21, KTH, Stockholm, 13:00 (English)
Opponent
Supervisors
Note

QC 20171018

Available from: 2017-10-18 Created: 2017-10-17 Last updated: 2017-10-18Bibliographically approved

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