Laboratory x-ray fluorescence tomography for high-resolution nanoparticle bio-imaging
2014 (English)In: Optics Letters, ISSN 0146-9592, E-ISSN 1539-4794, Vol. 39, no 9, 2790-2793 p.Article in journal (Refereed) Published
We demonstrate that nanoparticle x-ray fluorescence computed tomography in mouse-sized objects can be performed with very high spatial resolution at acceptable dose and exposure times with a compact laboratory system. The method relies on the combination of the 24 keV line-emission from a high-brightness liquid-metal-jet x-ray source, pencil-beam-forming x-ray optics, photon-counting energy-dispersive detection, and carefully matched (Mo) nanoparticles. Phantom experiments and simulations show that the arrangement significantly reduces Compton background and allows 100 mu m detail imaging at dose and exposure times compatible with small-animal experiments. The method provides a possible path to in vivo molecular x-ray imaging at sub-100 mu m resolution in mice.
Place, publisher, year, edition, pages
2014. Vol. 39, no 9, 2790-2793 p.
Computerized tomography, Experiments, High energy forming, Mammals, Optical tomography, High brightness, High resolution, Laboratory system, Phantom experiment, Photon counting, Very high spatial resolutions, X ray fluorescence, X-ray fluorescence computed tomography
Other Physics Topics
IdentifiersURN: urn:nbn:se:kth:diva-146145DOI: 10.1364/OL.39.002790ISI: 000335496400067ScopusID: 2-s2.0-84899677765OAI: oai:DiVA.org:kth-146145DiVA: diva2:723009
FunderSwedish Research Council
QC 201406102014-06-102014-06-092014-06-10Bibliographically approved