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Laboratory x-ray fluorescence tomography for high-resolution nanoparticle bio-imaging
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0003-2723-6622
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0002-9637-970X
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics, Biomedical and X-ray Physics.ORCID iD: 0000-0002-9487-669X
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2014 (English)In: Optics Letters, ISSN 0146-9592, E-ISSN 1539-4794, Vol. 39, no 9, p. 2790-2793Article in journal (Refereed) Published
Abstract [en]

We demonstrate that nanoparticle x-ray fluorescence computed tomography in mouse-sized objects can be performed with very high spatial resolution at acceptable dose and exposure times with a compact laboratory system. The method relies on the combination of the 24 keV line-emission from a high-brightness liquid-metal-jet x-ray source, pencil-beam-forming x-ray optics, photon-counting energy-dispersive detection, and carefully matched (Mo) nanoparticles. Phantom experiments and simulations show that the arrangement significantly reduces Compton background and allows 100 mu m detail imaging at dose and exposure times compatible with small-animal experiments. The method provides a possible path to in vivo molecular x-ray imaging at sub-100 mu m resolution in mice.

Place, publisher, year, edition, pages
2014. Vol. 39, no 9, p. 2790-2793
Keywords [en]
Computerized tomography, Experiments, High energy forming, Mammals, Optical tomography, High brightness, High resolution, Laboratory system, Phantom experiment, Photon counting, Very high spatial resolutions, X ray fluorescence, X-ray fluorescence computed tomography
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Identifiers
URN: urn:nbn:se:kth:diva-146145DOI: 10.1364/OL.39.002790ISI: 000335496400067Scopus ID: 2-s2.0-84899677765OAI: oai:DiVA.org:kth-146145DiVA, id: diva2:723009
Funder
Swedish Research Council
Note

QC 20140610

Available from: 2014-06-10 Created: 2014-06-09 Last updated: 2017-12-05Bibliographically approved

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Hertz, Hans M.Larsson, Jakob C.Larsson, Daniel H.

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