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Disposable Chip to Enable Metering in Dried Blood Spot Sampling
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.
Karolinska University Hospital. (Deptartment of Laboratory Medicine)
KTH, School of Electrical Engineering (EES), Micro and Nanosystems.ORCID iD: 0000-0001-9552-4234
Karolinska University Hospital. (Department of Medicine, Division of Clinical Pharmacology)
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2013 (English)Conference paper, Abstract (Refereed)
Abstract [en]

This work presents a disposable chip for metering and transferring an exactly defined liquid volume into a paper matrix by capillary filling and emptying of a microchannel together with self-actuated dissolvable valves. Once a liquid droplet of 20-50 μl is applied to the chip, a volume of 1 μl is automatically metered, separated from the applied volume and subsequently transferred into conventional Whatman 903 paper used in Dried Blood Spot (DBS) sampling. The presented concept allows accurate volume metering for lateral flow devices and is here designed to the specific purpose of metering blood spots for DBS analysis. The material costs for each chip are below 0.04 €.

Place, publisher, year, edition, pages
Keyword [en]
DBS. Dried Blood Spot, Metering, Dissolvable Valving
National Category
Other Medical Engineering
Research subject
Medical Technology
URN: urn:nbn:se:kth:diva-146627OAI: diva2:724269

QC 20140613

Available from: 2014-06-12 Created: 2014-06-12 Last updated: 2014-06-13Bibliographically approved

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Lenk, GabrielStemme, GöranRoxhed, Niclas
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