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CCL2 mediates anti-fibrotic effects in human fibroblasts independently of CCR2
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
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2014 (English)In: International Immunopharmacology, ISSN 1567-5769, E-ISSN 1878-1705, Vol. 20, no 1, 66-73 p.Article in journal (Refereed) Published
Abstract [en]

CCL2 is known for its major role as a chemoattractant of monocytes for immunological surveillance and to site of inflammation. CCL2 acts mainly through the G-protein-coupled receptor CCR2 but has also been described to mediate its effects independently of this receptor in vitro and in vivo. Emerging pieces of evidence indicate that the CCL2/CCR2 axis is involved in fibrotic diseases, such as increased plasma levels of CCL2 and the presence of CCL2-hyperresponsive fibroblasts explanted from patients with systemic sclerosis and idiopathic pulmonary fibrosis. One of the profibrotic key mediators is the myofibroblast characterized by overexpression of alpha-smooth muscle actin and collagen I. However, the correlation between the CCL2/CCR2 axis and the activation of fibroblasts is not yet fully understood. We have screened human fibroblasts of various origins, human pulmonary fibroblasts (HPF), human fetal lung fibroblasts (HFL-1) and primary preadipocytes (SPF-1) in regard to CCL2 stimulated fibrotic responses. Surprisingly we found that CCL2 mediates anti-fibrotic effects independently of CCR2 in human fibroblasts of different origins.

Place, publisher, year, edition, pages
2014. Vol. 20, no 1, 66-73 p.
Keyword [en]
CCL2, CCR2, Fibroblast, Preadipocyte, Fibrosis
National Category
Immunology in the medical area
URN: urn:nbn:se:kth:diva-147051DOI: 10.1016/j.intimp.2014.02.020ISI: 000336337900009ScopusID: 2-s2.0-84896350707OAI: diva2:728451
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Available from: 2014-06-24 Created: 2014-06-23 Last updated: 2014-06-24Bibliographically approved

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Stadler, CharlotteKvastad, LindaJohansson, Elin
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Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLabGene Technology
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