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Hyperbranched Polymer Architecturesas Theranostic Nanoparticles
KTH, School of Chemical Science and Engineering (CHE).
2012 (English)Independent thesis Advanced level (professional degree), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Three different hydrophobic hyperbranched random copolymers were synthesized by utilizing atom

transfer radical self condensing vinyl copolyerization (ATR-SCVCP) of the inimer 2-((2-bromo-2-

methylpropanoyl)oxy)ethyl methacrylate (BPEMA) together with a co-monomer hexyl acrylate in the

presence of a trifunctional atom transfer radical polymerization (ATRP) initiator. The polymerizations

give three different cores with a molecular weight of 5, 6, and 15 kg/mol, showing polydispersity

indices of 1.4 and 1.5. These hyperbranched random copolymers were designed to serve as

macroinitiators for further chain extensions. Linear hydrophilic segments were polymerized from the

macroinititors by using ATRP of the monomers 2,2,2-trifluoroethyl methacrylate (TFEMA) and

oligo(ethylene glycol) methyl ether methacrylate (OEGMA). From each core two different chain

lenghts of P(OEGMA-co-TFEMA) were synthesized as determined by 1H-NMR and size exclusion

chromatography (SEC). Molecular weights of P(OEGMA-co-TFEMA) ranging between 5-6 kg/mol

and 11-15 kg/mol were achieved from each of the three core moieties, determined by 1H-NMR. These

amphiphilic structures were allowed to self-assemble into micelles in phosphate buffered saline (PBS)

solutions and their hydrodynamic radius were determined by dynamic light scattering (DLS). Results

show that the micelles had a hydrodynamic radius of 9-20 nm depending on the core size, and arm

length. The micelles were further investigated by flouresence spectroscopy confirming that they form

stable core/shell nanoparticles with low critical micelle concentrations (CMCs). In addition, the

feasibility of the synthesized polymer nanoparticles to serve as a possible contrast agents for magnetic

resonance imaging (MRI) was strengthen since they all showed single narrow peaks using 19F-NMR.

Place, publisher, year, edition, pages
2012. , 54 p.
National Category
Engineering and Technology
URN: urn:nbn:se:kth:diva-147515OAI: diva2:730215
Available from: 2014-06-27 Created: 2014-06-27 Last updated: 2014-06-27Bibliographically approved

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