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The age and genomic integrity of neurons after cortical stroke in humans
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2014 (English)In: Nature Neuroscience, ISSN 1097-6256, E-ISSN 1546-1726, Vol. 17, no 6, 801-803 p.Article in journal (Refereed) Published
Abstract [en]

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived C-14 concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

Place, publisher, year, edition, pages
2014. Vol. 17, no 6, 801-803 p.
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Neurosciences
Identifiers
URN: urn:nbn:se:kth:diva-147420DOI: 10.1038/nn.3706ISI: 000336638000013Scopus ID: 2-s2.0-84901670239OAI: oai:DiVA.org:kth-147420DiVA: diva2:731246
Funder
Swedish Research CouncilSwedish Cancer SocietyKnut and Alice Wallenberg Foundation
Note

QC 20140701

Available from: 2014-07-01 Created: 2014-06-27 Last updated: 2017-12-05Bibliographically approved

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Werne Solnestam, BeataSigurgeirsson, BenjaminLundeberg, Joakim
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