Change search
ReferencesLink to record
Permanent link

Direct link
The age and genomic integrity of neurons after cortical stroke in humans
Show others and affiliations
2014 (English)In: Nature Neuroscience, ISSN 1097-6256, Vol. 17, no 6, 801-803 p.Article in journal (Refereed) Published
Abstract [en]

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived C-14 concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

Place, publisher, year, edition, pages
2014. Vol. 17, no 6, 801-803 p.
National Category
URN: urn:nbn:se:kth:diva-147420DOI: 10.1038/nn.3706ISI: 000336638000013ScopusID: 2-s2.0-84901670239OAI: diva2:731246
Swedish Research CouncilSwedish Cancer SocietyKnut and Alice Wallenberg Foundation

QC 20140701

Available from: 2014-07-01 Created: 2014-06-27 Last updated: 2014-07-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Werne Solnestam, BeataSigurgeirsson, BenjaminLundeberg, Joakim
By organisation
Gene TechnologyScience for Life Laboratory, SciLifeLab
In the same journal
Nature Neuroscience

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 32 hits
ReferencesLink to record
Permanent link

Direct link