The age and genomic integrity of neurons after cortical stroke in humans
2014 (English)In: Nature Neuroscience, ISSN 1097-6256, Vol. 17, no 6, 801-803 p.Article in journal (Refereed) Published
It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived C-14 concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.
Place, publisher, year, edition, pages
2014. Vol. 17, no 6, 801-803 p.
IdentifiersURN: urn:nbn:se:kth:diva-147420DOI: 10.1038/nn.3706ISI: 000336638000013ScopusID: 2-s2.0-84901670239OAI: oai:DiVA.org:kth-147420DiVA: diva2:731246
FunderSwedish Research CouncilSwedish Cancer SocietyKnut and Alice Wallenberg Foundation
QC 201407012014-07-012014-06-272014-07-01Bibliographically approved