Lipase-catalyzed asymmetric synthesis of oxathiazinanones through dynamic covalent kinetic resolution
2014 (English)In: Organic and biomolecular chemistry, ISSN 1477-0520, E-ISSN 1477-0539, Vol. 12, no 22, 3572-3575 p.Article in journal (Refereed) Published
A domino addition-lactonization pathway has been applied to a dynamic covalent resolution protocol, leading to efficient oxathiazinanone formation as well as chiral discrimination. A new, double biocatalytic pathway has furthermore been proposed and evaluated where the initial product inhibition could be efficiently circumvented.
Place, publisher, year, edition, pages
2014. Vol. 12, no 22, 3572-3575 p.
IdentifiersURN: urn:nbn:se:kth:diva-147756DOI: 10.1039/c4ob00365aISI: 000336782000006ScopusID: 2-s2.0-84900819904OAI: oai:DiVA.org:kth-147756DiVA: diva2:732401
FunderSwedish Research Council
QC 201407042014-07-042014-07-032014-11-19Bibliographically approved