Change search
ReferencesLink to record
Permanent link

Direct link
Characterization of Leukocyte Formin FMNL1 Expression in Human Tissues
Show others and affiliations
2014 (English)In: Journal of Histochemistry and Cytochemistry, ISSN 0022-1554, E-ISSN 1551-5044, Vol. 62, no 6, 460-470 p.Article in journal (Refereed) Published
Abstract [en]

Formins are cytoskeleton regulating proteins characterized by a common FH2 structural domain. As key players in the assembly of actin filaments, formins direct dynamic cytoskeletal processes that influence cell shape, movement and adhesion. The large number of formin genes, fifteen in the human, suggests distinct tasks and expression patterns for individual family members, in addition to overlapping functions. Several formins have been associated with invasive cell properties in experimental models, linking them to cancer biology. One example is FMNL1, which is considered to be a leukocyte formin and is known to be overexpressed in lymphomas. Studies on FMNL1 and many other formins have been hampered by a lack of research tools, especially antibodies suitable for staining paraffin-embedded formalin-fixed tissues. Here we characterize, using bioinformatics tools and a validated antibody, the expression pattern of FMNL1 in human tissues and study its subcellular distribution. Our results indicate that FMNL1 expression is not restricted to hematopoietic tissues and that neoexpression of FMNL1 can be seen in epithelial cancer.

Place, publisher, year, edition, pages
2014. Vol. 62, no 6, 460-470 p.
Keyword [en]
FMNL1, FRL1, formin, actin cytoskeleton, immunohistochemistry
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-147953DOI: 10.1369/0022155414532293ISI: 000337598700006ScopusID: 2-s2.0-84901454133OAI: diva2:733978

QC 20140714

Available from: 2014-07-14 Created: 2014-07-10 Last updated: 2014-07-14Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Uhlen, Mathias
By organisation
Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLab
In the same journal
Journal of Histochemistry and Cytochemistry
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 46 hits
ReferencesLink to record
Permanent link

Direct link