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Forensic Informativity of similar to 3000bp of Coding Sequence of Domestic Dog mtDNA
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
KTH, School of Biotechnology (BIO), Gene Technology. KTH, Centres, Science for Life Laboratory, SciLifeLab.
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2014 (English)In: Journal of Forensic Sciences, ISSN 0022-1198, E-ISSN 1556-4029, Vol. 59, no 4, 898-908 p.Article in journal (Refereed) Published
Abstract [en]

The discriminatory power of the noncoding control region (CR) of domestic dog mitochondrial DNA alone is relatively low. The extent to which the discriminatory power could be increased by analyzing additional highly variable coding regions of the mitochondrial genome (mtGenome) was therefore investigated. Genetic variability across the mtGenome was evaluated by phylogenetic analysis, and the three most variable similar to 1kb coding regions identified. We then sampled 100 Swedish dogs to represent breeds in accordance with their frequency in the Swedish population. A previously published dataset of 59 dog mtGenomes collected in the United States was also analyzed. Inclusion of the three coding regions increased the exclusion capacity considerably for the Swedish sample, from 0.920 for the CR alone to 0.964 for all four regions. The number of mtDNA types among all 159 dogs increased from 41 to 72, the four most frequent CR haplotypes being resolved into 22 different haplotypes.

Place, publisher, year, edition, pages
2014. Vol. 59, no 4, 898-908 p.
Keyword [en]
forensic science, domestic dog, mitochondrial DNA, coding region, control region, exclusion capacity
National Category
Industrial Biotechnology
URN: urn:nbn:se:kth:diva-148371DOI: 10.1111/1556-4029.12504ISI: 000338038300003ScopusID: 2-s2.0-84903387434OAI: diva2:736749
Knut and Alice Wallenberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience

QC 20140808

Available from: 2014-08-08 Created: 2014-08-05 Last updated: 2014-08-08Bibliographically approved

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Angleby, HelenOskarsson, MattiasArvestad, LarsLundeberg, Joakim
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Gene TechnologyScience for Life Laboratory, SciLifeLabComputational Biology, CB
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