Bioaccessibility of FERRO-chromium and ferrosilicon-chromium particles compared to pure metals and stainless steel-Aspects of human exposure
2010 (English)In: Proceedings of the 12th International Ferroalloys Congress: Sustainable Future, 2010, 43-51 p.Conference paper (Refereed)
Product safety legislation requires that industry indentifies and demonstrates any human risks associated with the manufacture and use of products which are placed on the market throughout their entire life cycle. This process involves detailed assessment of potential hazards of the products/material related to health effect endpoints, and requires accurate generation and interpretation of data which can be used to determine essential characteristics of the material. Temporary or permanent adverse health effects depend either on the shape or physical characteristics of the particles, and/or on chemical interactions with the particle surface upon human exposure. Since alloys represent the most significant and widespread use of many engineering metals, it is important to develop a detailed understanding of the characteristics and behaviour of this group of materials with a minimum dependence on in-vivo testing. The aim of this presentation is to summarize generated bioaccessibility data for ferro-chromium and ferro-silicon-chromium alloys in particulate form when exposed to different synthetic biological media. The selection of test media aims to mimic relevant human exposures, as far as practical, with the focus on inhalation and subsequent ingestion of inhaled particles. The generation of bioaccessibility data combined with detailed particle and material characterization, also from a surface perspective, is essential for accurate risk assessment and understanding of potential adverse effects that may be caused by ferro-chromium and ferro-silicon-chromium alloys. For comparison, a similar approach has been conducted on particles of pure iron, pure chromium and stainless steel grade AISI 316L. Generated data is used within the framework of risk assessment on ferro-chromium and ferro-siliconchromium alloys conducted by the Finnish Institute of Occupational Health, Helsinki, Finland.
Place, publisher, year, edition, pages
2010. 43-51 p.
Adverse effect, Adverse health effects, Bioaccessibility, Biological media, Chemical interactions, Essential characteristic, Finnish, Health effects, Helsinki, Finland, Human exposures, Human risks, In-vivo, Inhaled particles, Interpretation of data, Material characterizations, Occupational health, Particle surface, Physical characteristics, Potential hazards, Product safety, Pure iron, Pure metals, Stainless steel grades, Accident prevention, Chromium alloys, Health hazards, Industrial hygiene, Risk assessment, Silicon steel, Chromium
Other Chemistry Topics
IdentifiersURN: urn:nbn:se:kth:diva-148862ScopusID: 2-s2.0-84866130336ISBN: 978-952927340-9OAI: oai:DiVA.org:kth-148862DiVA: diva2:738122
12th International Ferroalloys Congress, INFACON 2010, 6 June 2010 through 9 June 2010, Helsinki, Finland
QC 201408152014-08-152014-08-142014-08-15Bibliographically approved