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Lewis Acid Mediated Alkylation and Diels-Alder Reactions of 2H-Azirines
KTH, Superseded Departments, Chemistry.
2002 (English)Licentiate thesis, comprehensive summary (Other scientific)
Abstract [en]

This thesis describes the use of 2H-azirines as reactivesubstrates in Lewis acid catalysed nucleophilic additions andin the Diels-Alder reaction.A number of carbon nucleophiles have been added to aseries of 2H-azirines in the presence and absence ofBF3·Et2O. 3-(2-Naphthyl)-2H-azirine has been used as amodel substrate in the enantioselective addition oforganolithium reagents to an 2H-azirine.A selection of Lewis acids has been screened for theirpossible use in the normal electron demand Diels-Alder reactionbetween 3-alkyl-, 3-aryl-, and 3- carboxyl-2H-azirines and avariety of dienes. Lewis acid activation was found to shortenreaction times and facilitate lower reaction temperatures.These cycloadditions proceeded with endo selectivity providinga single diastereoisomeric product.DFT calculations of Lewis acid activated 2H-azirineshave been carried out.

Keywords:2H-azirines, Lewis acid activation, chiralligands, organolithium reagents, Diels-Alder reactions,DFT-calculations

Place, publisher, year, edition, pages
Stockholm: Kemi , 2002. , 38 p.
Trita-IOK, ISSN 1100-7974 ; 2002:74
Keyword [en]
2H-azirines, Lewis acid activation, chiral ligandsorganolithium reagentsDiels-Alder reactions, DFT-calculations
URN: urn:nbn:se:kth:diva-1489ISBN: 91-7283-365-3OAI: diva2:7389
NR 20140805Available from: 2002-10-09 Created: 2002-10-09Bibliographically approved

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