A theoretical assessment of the influence of myosin filament dispersion on smooth muscle contraction
2011 (English)In: ASME 2011 Summer Bioengineering Conference, 2011, no PARTS A AND B, 145-146 p.Conference paper (Refereed)
A new constitutive model for the biomechanical behavior of smooth muscle tissue is employed to investigate the influence of statistical dispersion in the orientation of myosin filaments. The number of activated cross-bridges between the actin and myosin filaments governs the contractile force generated by the muscle and also the contraction speed. A strain-energy function is used to describe the mechanical behavior of the smooth muscle tissue. The predictions from the constitutive model are compared to histological and isometric tensile test results for smooth muscle tissue from swine carotid artery. In order to be able to predict the active stress at different muscle lengths, a filament dispersion significantly larger than the one observed experimentally was required. Furthermore, a comparison of the predicted active stress for a case of uniaxially oriented myosin filaments and a case of filaments with a dispersion based on the experimental histological data shows that the difference in generated stress is noticeable but limited. Thus, the results suggest that myosin filament dispersion alone cannot explain the increase in active muscle stress with increasing muscle stretch. Copyright © 2011 by ASME.
Place, publisher, year, edition, pages
2011. no PARTS A AND B, 145-146 p.
Biomechanical behavior, Contractile force, Histological data, Mechanical behavior, Myosin filaments, Smooth muscle contractions, Statistical dispersion, Strain energy functions, Constitutive models, Dispersions, Proteins, Tensile testing, Muscle
IdentifiersURN: urn:nbn:se:kth:diva-148746DOI: 10.1115/SBC2011-53071ScopusID: 2-s2.0-84881228524ISBN: 9780791854587OAI: oai:DiVA.org:kth-148746DiVA: diva2:740397
ASME 2011 Summer Bioengineering Conference, SBC 2011, 22 June 2011 through 25 June 2011, Farmington, PA
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