Change search
ReferencesLink to record
Permanent link

Direct link
Fast DNA sequencing via transverse differential conductance
KTH, School of Industrial Engineering and Management (ITM), Materials Science and Engineering, Applied Material Physics. Uppsala University, Uppsala, Sweden .
Show others and affiliations
2010 (English)In: SISPAD 2010 - 15th International Conference on Simulation Of Semiconductor Processes and Devices, IEEE , 2010, 313-316 p.Conference paper (Refereed)
Abstract [en]

We propose using characteristic transverse differential conductance for solid-state nanopore-based DNA sequencing and have explored this idea by performing molecular dynamics simulations on the translocation progress of single-stranded DNA molecule through the nanopore, and calculating the associated transverse differential conductance. Our results show that measurement of the transverse differential conductance is suitable to successfully discriminate between the four nucleotide types, and we show that this identification could even withstand electrical noise caused by fluctuations due to changes in the DNA orientation. Our findings demonstrate several compelling advantages of the differential conductance approach, which may lead to important applications in rapid genome sequencing.

Place, publisher, year, edition, pages
IEEE , 2010. 313-316 p.
, International Conference on Simulation of Semiconductor Processes and Devices, ISSN 1946-1569
Keyword [en]
Differential conductances, DNA Sequencing, Electrical noise, Genome sequencing, Molecular dynamics simulations, Single-stranded DNA molecules, Solid-state nanopore
National Category
Medical Engineering
URN: urn:nbn:se:kth:diva-149686DOI: 10.1109/SISPAD.2010.5604495ISI: 000283778800002ScopusID: 2-s2.0-78649568967ISBN: 978-142447699-2OAI: diva2:741563
15th International Conference on Simulation of Semiconductor Processes and Devices, SISPAD 2010, 6 September 2010 through 8 September 2010, Bologna, Italy

QC 20140828

Available from: 2014-08-28 Created: 2014-08-26 Last updated: 2014-08-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Ahuja, Rajeev
By organisation
Applied Material Physics
Medical Engineering

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 19 hits
ReferencesLink to record
Permanent link

Direct link