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Immunoselective cellulose nanospheres: a versatile platform for nanotheranostics
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Fibre Technology.ORCID iD: 0000-0002-4511-1076
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Fibre Technology. KTH, School of Chemical Science and Engineering (CHE), Centres, Wallenberg Wood Science Center.ORCID iD: 0000-0001-8622-0386
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Fibre Technology.ORCID iD: 0000-0002-7410-0333
2014 (English)In: ACS Macro Letters, E-ISSN 2161-1653, Vol. 3, no 11, 1117-1120 p.Article in journal (Refereed) Published
Abstract [en]

This paper describes a novel route for the preparation and functionalization of perfectly spherical cellulose nanospheres (CNSs), ranging from 100 to 400 nrn with a typical diameter of 160-170 nrn,for use in theranostics. The method of preparation enables both surface and interior bulk functionalization, and this presumably also makes the CNSs suitable for use in end-use applications other than theranostics. Surface functionalization was here demonstrated by antibody conjugation with an antibody specific toward the epidermal growth factor receptor (EGFR) protein, i.e., facilitating interaction with cancer cells having the EGFR. Besides showing specificity, the CNS-antibody conjugates showed a very low nonspecific binding. The CNSs could easily be bulk functionalized by embedding gold nanoparticles in the cellulose sphere matrix during CNS preparation to provide imaging contrast for diagnostic purposes.

Place, publisher, year, edition, pages
2014. Vol. 3, no 11, 1117-1120 p.
National Category
Polymer Chemistry
URN: urn:nbn:se:kth:diva-150104DOI: 10.1021/mz500507kISI: 000345264800004ScopusID: 2-s2.0-84910641012OAI: diva2:741824

QC 20150115

Available from: 2014-08-29 Created: 2014-08-29 Last updated: 2015-05-26Bibliographically approved
In thesis
1. Macro-, Micro- and Nanospheres from Cellulose: Their Preparation, Characterization and Utilization
Open this publication in new window or tab >>Macro-, Micro- and Nanospheres from Cellulose: Their Preparation, Characterization and Utilization
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The structure of a polymeric material has a great influence in many fundamental scientific areas as well as in more applied science, since it affects the diffusion, permeability, mechanical strength, elasticity, and colloidal properties of the materials. The results in this thesis demonstrate that it is possible to fabricate solid and hollow cellulose spheres with a cellulose shell and encapsulated gas, liquid or solid particles and with a sphere size ranging from a few hundreds of nanometres to several millimetres, all with a tailored design and purpose.

The sizes of the different spheres have been controlled by three different preparation methods: large cellulose macrospheres by a solution solidification procedure, hollow micrometre-sized cellulose spheres by a liquid flow-focusing technique in microchannels, and nanometre-sized cellulose spheres by a membrane emulsification technique. 

The spheres were then modified in different ways in order to functionalize them into more advanced materials. This thesis demonstrates how to control the cellulose sphere dimensions and the wall-to-void volume ratio, the elasticity and the functionality of the spheres as such, where they were prepared to be pH-responsive, surface specific and X-ray active. These modifications are interesting in several different types of final materials such as packaging materials, drug release devices or advanced in vivo diagnostic applications.

In the more fundamental science approach, surface-smooth solid cellulose spheres were prepared for characterization of the macroscopic work of adhesion when a cellulose surface is separated from another material. Using these ultra-smooth macroscopic cellulose probes, it is possible to measure the compatibility and the surface interactions between cellulose and other materials which provide an important tool for incorporating cellulose into different composite materials. 

Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2014. 67 p.
TRITA-CHE-Report, ISSN 1654-1081 ; 2014:32
Cellulose, sphere, capsule, functionalization
National Category
Polymer Technologies
Research subject
Fibre and Polymer Science
urn:nbn:se:kth:diva-149807 (URN)978-91-7595-231-4 (ISBN)
Public defence
2014-09-26, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:00 (English)

QC 20140829

Available from: 2014-08-29 Created: 2014-08-27 Last updated: 2014-08-29Bibliographically approved

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Carrick, ChristopherWågberg, LarsLarsson, Per A.
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