Change search
ReferencesLink to record
Permanent link

Direct link
Hydrolysis of RNA by a lanthanide salen - cyclodextrin complex
KTH, School of Biotechnology (BIO).
2013 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

This is a report focusing on further development of a synthetic catalyst for hydrolysis of the phosphate ester bonds in RNA. The main goal was to construct a catalyst based on a cyclodextrin ligand suitable for carrying a lanthanide metal with the induced capability to hydrolyse the stable phosphate ester bonds in RNA. This was achieved through a six-step synthesis resulting in a lanthanide-salen-cyclodextrin complex. For simplicity in the product analysis of the reaction, adenosine diribonucleotide (ApA) was used as a model substrate for RNA. The hydrolysis was performed at 20°C and ph7 to mimic physiological conditions in the human body. The results showed indications that it was possible to hydrolysis RNA by this kind of complex.

Place, publisher, year, edition, pages
National Category
Engineering and Technology
URN: urn:nbn:se:kth:diva-149649OAI: diva2:744695
Available from: 2015-06-29 Created: 2014-08-25 Last updated: 2015-09-23Bibliographically approved

Open Access in DiVA

No full text

By organisation
School of Biotechnology (BIO)
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 12 hits
ReferencesLink to record
Permanent link

Direct link