Change search
ReferencesLink to record
Permanent link

Direct link
The early diastolic myocardial velocity: A marker of increased risk in patients with coronary heart disease
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.ORCID iD: 0000-0002-5156-2535
KTH, School of Technology and Health (STH), Medical Engineering. Karolinska Institute, Sweden.
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
KTH, School of Technology and Health (STH), Medical Engineering, Medical Imaging.
Show others and affiliations
2014 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 34, no 5, 389-396 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Tissue Doppler imaging (TDI) is a promising echocardiographic modality allowing quantification of myocardial performance. However, the prognostic potential of TDI in patients with acute myocardial infarction (AMI) is not yet investigated. We sought to explore the ability of TDI in identifying patients at risk for new cardiovascular events after AMI. Methods: One hundred and nineteen patients with AMI were recruited prospectively (mean age 61 years; range 32-81 years of age). Patients with diabetes mellitus (DM) were excluded. Echocardiography was performed 3-12 months after AMI. Two-dimensional (2-D) and TDI variables were recorded. The patients were followed during a mean period of 4·6 years (range 1-8 years). The primary end-point was defined as any of the following: death from any cause, non-fatal reinfarction or stroke, unstable angina pectoris, congestive heart failure requiring hospitalization and coronary revascularization procedure. Results: Thirty patients had some form of cardiovascular events during follow-up. Seven patients had cardiovascular death, 13 patients had reinfarction and four patients had a stroke. New angina or unstable angina was recorded in 21 patients. Of these patients, 13 underwent percutaneous coronary angioplasty (PCI) or coronary artery bypass grafting (CABG). The early diastolic myocardial velocity (Em) emerged as the only echocardiographic variable that offered a clear differentiation between patients that presented with new cardiovascular (CV) events as compared to the corresponding group without any CV events at follow-up (P<0·05). In multivariate statistical analysis and after adjustment for age, sex, total cholesterol, body mass index (BMI) and other baseline characteristics, Em remained as independent predictors of CV events (HR, 1·18, 95% CI, 1·02-1·36; P<0·05). However, none of the investigated variables evolved as an independent predictor of cardiovascular morbidity and mortality. Conclusion: Em appears to be a sensitive echocardiographic index in identifying non-diabetic patients with AMI at risk of new cardiovascular events.

Place, publisher, year, edition, pages
2014. Vol. 34, no 5, 389-396 p.
Keyword [en]
Early myocardial diastolic velocity, Myocardial infarction, Tissue velocity imaging
National Category
Medical Image Processing
URN: urn:nbn:se:kth:diva-151043DOI: 10.1111/cpf.12110ISI: 000341238500008ScopusID: 2-s2.0-84908356117OAI: diva2:747064

QC 20140915

Available from: 2014-09-15 Created: 2014-09-15 Last updated: 2015-04-30Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Johnson, JonasManouras, AristomenisBergholm, FredrikBrodin, Lars Åke
By organisation
Medical ImagingMedical Engineering
In the same journal
Clinical Physiology and Functional Imaging
Medical Image Processing

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 40 hits
ReferencesLink to record
Permanent link

Direct link