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Simulation of cerebral aneurysm growth and prediction of evolving rupture risk
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.).
2011 (English)In: Modelling and Simulation in Engineering, ISSN 1687-5591, Vol. 2011, 289523- p.Article in journal (Refereed) Published
Abstract [en]

Cerebral aneurysms are local expansions of blood vessel walls in the brain blood system. The rupture of an aneurysm is a very severe event associated with a high rate of mortality. When cerebral aneurysms are detected, clinicians need to decide if operation is required. The risk of aneurysm rupture is then compared to the risks associated with the medical intervention. In the present paper, a probabilistic framework for a mechanically based rupture risk assessment of cerebral aneurysms is proposed. The method is based on the assumption that the strength of aneurysmal tissues can be described by a statistical distribution. A structural analysis of the aneurysm in question is performed, and the maximum stress experienced by the aneurysm is compared to the strength distribution. The proposed model was compared with clinical results for ruptured aneurysms in terms of rupture density and accumulated rupture risk as a function of aneurysm size. The model was able to reproduce the clinical results well. The proposed framework may potentially be used under in vivo conditions to predict the risk of rupture for diagnosed aneurysms.

Place, publisher, year, edition, pages
2011. Vol. 2011, 289523- p.
National Category
Neurology
Identifiers
URN: urn:nbn:se:kth:diva-151132DOI: 10.1155/2011/289523Scopus ID: 2-s2.0-80052662826OAI: oai:DiVA.org:kth-151132DiVA: diva2:748938
Note

QC 20140922

Available from: 2014-09-22 Created: 2014-09-15 Last updated: 2015-10-09Bibliographically approved

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