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3D Finite element analysis of smooth muscle contraction considering calcium diffusion
KTH, School of Engineering Sciences (SCI), Solid Mechanics (Dept.). Graz University of Technology, Austria.
2009 (English)In: Computational plasticity X: fundamentals and applications, 2009Conference paper (Refereed)
Abstract [en]

Recently a model of the mechanochemical response of smooth muscle cells has been developed by Murtada et al. [1]. The model is based on a strain-energy function incorporating only a few physical-based material parameters. The main focus of their approach is on the modeling of the response of the cross-bridge interactions and on the related force generation. Based on a one-dimensional analysis the performance of the modeling approach has been shown by comparing to experimental data of smooth muscle cells. The results of the combined coupled model are broadly consistent with isometric and quick-release experiments on smooth muscle tissue. In the present study the aforementioned model has been implemented into a finite element program in order to solve more complex boundary-value problems. In doing so we present here a first three-dimensional simulation of the Fick's law-driven diffusion of calcium into a cell as well as the related smooth muscle contraction.

Place, publisher, year, edition, pages
Keyword [en]
3D mechanical modeling, Calcium, Smooth muscle contraction
National Category
Materials Engineering
URN: urn:nbn:se:kth:diva-151979ScopusID: 2-s2.0-84859150812ISBN: 978-849673669-6OAI: diva2:749247
10th International Conference on Computational Plasticity, COMPLAS X, 2 September 2009 through 4 September 2009, Barcelona, Spain

QC 20140923

Available from: 2014-09-23 Created: 2014-09-23 Last updated: 2014-09-23Bibliographically approved

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Holzapfel, Gerhard A.
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