A multi-scale collagen turn-over model for soft biological tissues with application to abdominal aortic aneurysm growth
2011 (English)In: ASME 2011 Summer Bioengineering Conference, SBC 2011, 2011, no PARTS A AND B, 689-690 p.Conference paper (Refereed)
Collagen is a structural protein responsible for the mechanical strength, stiffness and toughness of biological tissues like skin, tendon, bone, cornea, lung and vasculature. In the present study we considered the enlargement of the aneurysm as a consequence of a pathological degradation and synthesis of collagen, i.e. malfunction of collagen turn-over. Consequently, the vascular wall is modeled by an (inert) matrix material representing the elastin, which is reinforced by a dynamic structure of bundles of collagen. Specifically, collagen is formed by a continuous stress-mediated process: deposited in the current configuration and removed by a constant degradation rate. Finally the micro-plane concept is used for the Finite Element implementation of the constitutive law. The model proposed within this study has a strong biological motivation and is able to capture both non-linear mechanics of aortic tissue and saline feature of AAA growth. Besides that, the micro-plane approach allows a straight forward FE implementation and preliminary results indicate its numerical robustness.
Place, publisher, year, edition, pages
2011. no PARTS A AND B, 689-690 p.
Abdominal aortic aneurysms, Biological motivations, Current configuration, Finite element implementation, Nonlinear mechanics, Numerical robustness, Soft biological tissue, Structural proteins, Degradation, Tissue, Collagen
IdentifiersURN: urn:nbn:se:kth:diva-148683DOI: 10.1115/SBC2011-53076ScopusID: 2-s2.0-84881247354ISBN: 9780791854587OAI: oai:DiVA.org:kth-148683DiVA: diva2:749821
ASME 2011 Summer Bioengineering Conference, SBC 2011, 22 June 2011 through 25 June 2011, Farmington, PA, United States
QC 201409252014-09-252014-08-112014-09-25Bibliographically approved