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Aggregation and long-term positioning of cells by ultrasound in a multi-well microchip for high-resolution imaging of the natural killer cell immune synapse
KTH, School of Engineering Sciences (SCI), Applied Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics.ORCID iD: 0000-0002-7023-4772
KTH, School of Engineering Sciences (SCI), Applied Physics.
KTH, School of Engineering Sciences (SCI), Applied Physics.ORCID iD: 0000-0002-3996-9279
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2011 (English)In: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 2011, 329-331 p.Conference paper, Published paper (Refereed)
Abstract [en]

In this study we investigate the ability of Natural Killer (NK) cells to form ultrasound-mediated intercellular contacts with target cells in a multi-well microdevice by high-resolution confocal-microscopy imaging of inhibitory immune synapses. Furthermore, we compare the NK-Target cell cluster migration with and without ultrasound actuation. Experiments indicate that clusters of cells are positioned and maintained centered in the wells for 17 hours when they are exposed continuously to ultrasound. Our system can be used for both screening high numbers of events in low resolution and also for high resolution imaging of long term cell-cell interactions.

Place, publisher, year, edition, pages
2011. 329-331 p.
Keyword [en]
Immune synapse, Microchip, Multi-well, Natural killer cells, Ultrasound, Cell-cell interaction, High resolution, High-resolution imaging, Low resolution, Multi wells, Cytology, Image reconstruction, Microprocessor chips, Ultrasonics, Cells
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:kth:diva-148705Scopus ID: 2-s2.0-84883766949ISBN: 9781618395955 (print)OAI: oai:DiVA.org:kth-148705DiVA: diva2:751002
Conference
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 2 October 2011 through 6 October 2011, Seattle, WA
Note

QC 20140930

Available from: 2014-09-30 Created: 2014-08-11 Last updated: 2014-09-30Bibliographically approved

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Ohlin, MathiasÖnfelt, Björn

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Christakou, Athanasia. E.Ohlin, MathiasKhorshidi, Mohammad AliFrisk, ThomasVanherberghen, BrunoÖnfelt, BjörnWiklund, Martin
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  • apa
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