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Microfluidics for nano-pathophysiology
KTH, School of Biotechnology (BIO), Proteomics and Nanobiotechnology.
2014 (English)In: Advanced Drug Delivery Reviews, ISSN 0169-409X, E-ISSN 1872-8294, Vol. 74, 115-121 p.Article, review/survey (Refereed) Published
Abstract [en]

Nanotechnology-based drug delivery systems hold promise for innovative medical treatment of cancers. While drug materials are constantly under development, there are no practical cell-based models to assess whether these materials can reach the target tissue. Recently developed microfluidic systems have revolutionized cell-based experiments. In these systems, vascular endothelial cells and interstitium are set in microchannels that mimic microvessels. Drug permeability can be assayed in these blood vessel models under fluidic conditions that mimic blood flow. In this review, we describe device fabrication, disease model development, nanoparticle permeability assays, and the potential utility of these systems in the future.

Place, publisher, year, edition, pages
2014. Vol. 74, 115-121 p.
Keyword [en]
Microfluidics, Microdevice, Organs on a Chip, Disease model, Cardiovascular model
National Category
Pharmacology and Toxicology
URN: urn:nbn:se:kth:diva-153278DOI: 10.1016/j.addr.2013.08.009ISI: 000341482500011ScopusID: 2-s2.0-84906047759OAI: diva2:752683

QC 20141006

Available from: 2014-10-06 Created: 2014-10-03 Last updated: 2014-10-06Bibliographically approved

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Svahn, Helene Andersson
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