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Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism
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2014 (English)In: Thrombosis Research, ISSN 0049-3848, E-ISSN 1879-2472, Vol. 134, no 2, 426-432 p.Article in journal (Refereed) Published
Abstract [en]

Introduction: We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n = 2753) from Sweden. Materials and Methods: 39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression. Results: Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n = 7181). Conclusions: It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.

Place, publisher, year, edition, pages
2014. Vol. 134, no 2, 426-432 p.
Keyword [en]
Venous thromboembolism, Coronary artery disease, ANRIL, ABO, Genetics
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URN: urn:nbn:se:kth:diva-153277DOI: 10.1016/j.thromres.2014.03.054ISI: 000341309200036ScopusID: 2-s2.0-84905125152OAI: diva2:752690

QC 20141006

Available from: 2014-10-06 Created: 2014-10-03 Last updated: 2014-10-06Bibliographically approved

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Odeberg, Jacob
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Proteomics and NanobiotechnologyScience for Life Laboratory, SciLifeLab
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