Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas
Show others and affiliations
2008 (English)In: Cancer Genomics & Proteomics, ISSN 1109-6535, E-ISSN 1790-6245, Vol. 5, no 6, 293-300 p.Article in journal (Refereed) Published
Abstract [en]

Background: Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progression. Two proteins, TRP-1 and galectin-1, were identified as proteins with enhanced expression in cells from the melanocytic lineage. Patients and Methods: Protein profiling of TRP-1 and galectin-1 together with proliferation marker Ki-67 and melanocyte marker Melan-A was performed in normal tissues from 144 individuals and in 216 different tumors using tissue microarrays and immunohistochemistry. The protein expression pattern was further analyzed in a defined cohort of 157 patients diagnosed with invasive cutaneous malignant melanoma. Results: Both TRP-1 and galectin-1 were highly expressed in normal melanocytes and melanoma. The expression of TRP-1 was inversely correlated with tumor stage (p=0.002, (R=-0.28)). Neither TRP-1 or galectin-1 was associated with overall or disease free survival (p>0.14, p>0.46 respectively). Ki-67 was associated with tumor stage and survival (p<0.001). Conclusion: TRP-1 and galectin-1 protein expression patterns were determined in normal and cancer tissues and both proteins were expressed in the majority of the malignant melanomas. There was no correlation between TRP-1 or galectin-1 expression and survival.

Place, publisher, year, edition, pages
2008. Vol. 5, no 6, 293-300 p.
Keyword [en]
Galectin-1, Human Protein Atlas Program, Malignant melanoma, TRP-1, galectin 1, glycoprotein, Ki 67 antigen, melan A, molecular marker, protein antibody, protein TRP 1, unclassified drug, article, cancer growth, cancer staging, cancer tissue, controlled study, disease free survival, female, human, immunohistochemistry, major clinical study, male, melanocyte, melanoma, overall survival, protein analysis, protein expression, proteomics, skin carcinogenesis, tissue microarray, Disease-Free Survival, Follow-Up Studies, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Ki-67 Antigen, Melanocytes, Membrane Glycoproteins, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Proteins, Oxidoreductases, Retrospective Studies, Skin Neoplasms, Survival Rate
National Category
Medical Biotechnology
Identifiers
URN: urn:nbn:se:kth:diva-154189Scopus ID: 2-s2.0-58249106935OAI: oai:DiVA.org:kth-154189DiVA: diva2:755602
Note

QC 20141015

Available from: 2014-10-15 Created: 2014-10-14 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

No full text

Scopus

Authority records BETA

Uhlén, Mathias

Search in DiVA

By author/editor
Uhlén, Mathias
By organisation
Proteomics (closed 20130101)
In the same journal
Cancer Genomics & Proteomics
Medical Biotechnology

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 34 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf