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The protein expression of TRP-1 and galectin-1 in cutaneous malignant melanomas
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2008 (English)In: Cancer Genomics and Proteomics, Vol. 5, no 6, 293-300 p.Article in journal (Refereed) Published
Abstract [en]

Background: Patients with metastazing malignant melanoma have a poor outcome and determination of thickness of the primary tumor remains as the most important prognostic predictor. The aim of this study was to use an antibody-based proteomics strategy to search for new molecular markers associated with melanoma progression. Two proteins, TRP-1 and galectin-1, were identified as proteins with enhanced expression in cells from the melanocytic lineage. Patients and Methods: Protein profiling of TRP-1 and galectin-1 together with proliferation marker Ki-67 and melanocyte marker Melan-A was performed in normal tissues from 144 individuals and in 216 different tumors using tissue microarrays and immunohistochemistry. The protein expression pattern was further analyzed in a defined cohort of 157 patients diagnosed with invasive cutaneous malignant melanoma. Results: Both TRP-1 and galectin-1 were highly expressed in normal melanocytes and melanoma. The expression of TRP-1 was inversely correlated with tumor stage (p=0.002, (R=-0.28)). Neither TRP-1 or galectin-1 was associated with overall or disease free survival (p>0.14, p>0.46 respectively). Ki-67 was associated with tumor stage and survival (p<0.001). Conclusion: TRP-1 and galectin-1 protein expression patterns were determined in normal and cancer tissues and both proteins were expressed in the majority of the malignant melanomas. There was no correlation between TRP-1 or galectin-1 expression and survival.

Place, publisher, year, edition, pages
2008. Vol. 5, no 6, 293-300 p.
Keyword [en]
Galectin-1, Human Protein Atlas Program, Malignant melanoma, TRP-1, galectin 1, glycoprotein, Ki 67 antigen, melan A, molecular marker, protein antibody, protein TRP 1, unclassified drug, article, cancer growth, cancer staging, cancer tissue, controlled study, disease free survival, female, human, immunohistochemistry, major clinical study, male, melanocyte, melanoma, overall survival, protein analysis, protein expression, proteomics, skin carcinogenesis, tissue microarray, Disease-Free Survival, Follow-Up Studies, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Ki-67 Antigen, Melanocytes, Membrane Glycoproteins, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasm Proteins, Oxidoreductases, Retrospective Studies, Skin Neoplasms, Survival Rate
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Medical Biotechnology
URN: urn:nbn:se:kth:diva-154189ScopusID: 2-s2.0-58249106935OAI: diva2:755602

QC 20141015

Available from: 2014-10-15 Created: 2014-10-14 Last updated: 2014-10-16Bibliographically approved

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Uhlén, Mathias
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Proteomics (closed 20130101)
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