Bioaccessibility of nano- and micron-sized metallic particles in simulated lung systems
2008 (English)Conference paper (Refereed)
Ambient airborne particles of varying size and composition, originating from anthropogenic and natural sources are today a recognized health risk in the society. The rapid development of engineered nanomaterials, including particles, is believed to become an issue of large concern. At present, few efforts have been made to investigate potential adverse health effects of nano- and micron sized metallic particles. Reliable data on surface properties and reactivity of metallic particles and its correlation to toxicity is scarce. Bioaccessibility data, in terms of metal release, is believed to reflect the toxic effects of metallic particles. The metal release process is influenced by particle size, i.e. surface area, shape and material type, e.g. passive/non-passive, pure/alloy/oxide as well as the exposure environment, e.g. within the lung. The assessment of potentially adverse health effects due to particles requires the correlation between toxic effects, bioaccessibility properties and surface characteristics. Within this context, the material aspects of metal release from Cu-particles were studied in-vitro by exposure in different synthetic biological media that simulate, to some extent, a realistic inhalation scenario. Particle toxicity in terms of DNA damage and cytotoxic effects was studied in collaboration with human toxicologists at Karolinska Institutet, and aerosol scientists at Stockholm University, using epithelial human lung cells.
Place, publisher, year, edition, pages
2008. 1766-1772 p.
, 17th International Corrosion Congress 2008: Corrosion Control in the Service of Society, 3
Metal release, Nanoparticles, Particle size, Surface area, Toxicity, Adverse health effects, Ambient airborne particles, Bioaccessibility, Biological media, Cytotoxic effects, DNA damages, Engineered nanomaterials, Exposure environment, Human lung cells, In-vitro, Metallic particles, Natural sources, Stockholm University, Surface characteristics, Toxic effect, Biological materials, Biological organs, Corrosion prevention, Cytotoxicity, Industrial poisons, Surface properties, Surfaces
Materials Chemistry Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:kth:diva-153300ScopusID: 2-s2.0-84865005006ISBN: 9781615674251OAI: oai:DiVA.org:kth-153300DiVA: diva2:756419
17th International Corrosion Congress 2008: Corrosion Control in the Service of Society, 6-10 October 2008, Las Vegas, NV, USA
QC 201410172014-10-172014-10-032014-10-17Bibliographically approved