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Spermicidal activity of the safe natural antimicrobial peptide subtilosin
KTH, School of Biotechnology (BIO). Department of Microbiology and Molecular Genetics, Department of Food Science, Rutgers, The State University of New Jersey, United States .
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2008 (English)In: Infectious diseases in obstetrics and gynecology, ISSN 1064-7449, E-ISSN 1098-0997, Vol. 2008Article in journal (Refereed) Published
Abstract [en]

Bacterial vaginosis (BV), a condition affecting millions of women each year, is primarily caused by the gram-variable organism Gardnerella vaginalis. A number of organisms associated with BV cases have been reported to develop multidrug resistance, leading to the need for alternative therapies. Previously, we reported the antimicrobial peptide subtilosin has proven antimicrobial activity against G. vaginalis, but not against the tested healthy vaginal microbiota of lactobacilli. After conducting tissue sensitivity assays using an ectocervical tissue model, we determined that human cells remained viable after prolonged exposures to partially-purified subtilosin, indicating the compound is safe for human use. Subtilosin was shown to eliminate the motility and forward progression of human spermatozoa in a dose-dependent manner, and can therefore be considered a general spermicidal agent. These results suggest subtilosin would be a valuable component in topical personal care products aimed at contraception and BV prophylaxis and treatment.

Place, publisher, year, edition, pages
2008. Vol. 2008
Keyword [en]
antiinfective agent, spermicidal agent, subtilosin, unclassified drug, bacteriocin, cyclopeptide, sboA protein, Bacillus subtilis, antimicrobial activity, article, bacterial infection, cell viability, controlled study, dose response, drug safety, Gardnerella vaginalis, human, human cell, Lactobacillus, Lactobacillus casei, priority journal, quantitative analysis, spermatozoon, spermatozoon motility, vaginitis, animal, cell survival, cytology, drug effect, female, intravaginal drug administration, male, microbiology, rabbit, vagina, Administration, Intravaginal, Animals, Anti-Bacterial Agents, Bacteriocins, Humans, Peptides, Cyclic, Rabbits, Sperm Motility, Spermatocidal Agents, Spermatozoa, Vaginosis, Bacterial
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Health Sciences
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URN: urn:nbn:se:kth:diva-154311DOI: 10.1155/2008/540758PubMedID: 18923673Scopus ID: 2-s2.0-54249143112OAI: oai:DiVA.org:kth-154311DiVA: diva2:757093
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QC 20141021

Available from: 2014-10-21 Created: 2014-10-17 Last updated: 2017-12-05Bibliographically approved

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