Efficient Asymmetric Synthesis of 1-Cyano-tetrahydroisoquinolines from Lipase Dual Activity and Opposite Enantioselectivities in alpha-Aminonitrile Resolution
2014 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 20, no 36, 11322-11325 p.Article in journal (Refereed) Published
Dual promiscuous racemization/amidation activities of lipases leading to efficient dynamic kinetic resolution protocols of racemic alpha-aminonitrile compounds are described. alpha-Amidonitrile products of high enantiomeric purity could be formed in high yields. Several lipases from different sources were shown to exhibit the dual catalytic activities, where opposite enantioselectivities could be recorded for certain substrates.
Place, publisher, year, edition, pages
2014. Vol. 20, no 36, 11322-11325 p.
amidation, asymmetric synthesis, dynamic chemistry, enzymes, lipases, racemization
IdentifiersURN: urn:nbn:se:kth:diva-154383DOI: 10.1002/chem.201402615ISI: 000341629800012ScopusID: 2-s2.0-84906947818OAI: oai:DiVA.org:kth-154383DiVA: diva2:757195
FunderSwedish Research Council
QC 201410212014-10-212014-10-202014-10-21Bibliographically approved