Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Altered theta coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy
University of Freiburg, Germany.ORCID iD: 0000-0002-8044-9195
Show others and affiliations
2012 (English)In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, Vol. 53, no 11, 1937-1947 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Temporal lobe epilepsy is often accompanied by neuron loss and rewiring in the hippocampus. We hypothesized that the interaction of subnetworks of the entorhinalhippocampal loop between epileptic events should show significant signatures of these pathologic changes.

Methods: We combined simultaneous recording of local field potentials in entorhinal cortex (EC) and dentate gyrus (DG) in freely behaving kainate-injected mice with histologic analyses and computational modeling.

Key Findings: In healthy mice, theta band activity was synchronized between EC and DG. In contrast, in epileptic mice, theta activity in the EC was delayed with respect to the DG. A computational neural mass model suggests that hippocampal cell loss imbalances the coupling of subnetworks, introducing the shift.

Significance: We show that pathologic dynamics in epilepsy encompass ongoing activity in the entorhinal-hippocampal loop beyond acute epileptiform activity. This predominantly affects theta band activity, which links this shift in entorhinal-hippocampal interaction to behavioral aspects in epilepsy.

Place, publisher, year, edition, pages
2012. Vol. 53, no 11, 1937-1947 p.
Keyword [en]
Coupled networks, Hippocampus, Kainate, Phase shift, Synchronization
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:kth:diva-154863DOI: 10.1111/j.1528-1167.2012.03662.xISI: 000310975400013Scopus ID: 2-s2.0-84869074273OAI: oai:DiVA.org:kth-154863DiVA: diva2:758915
Note

QC 20150331

Available from: 2014-10-28 Created: 2014-10-28 Last updated: 2017-12-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Authority records BETA

Kumar, Arvind

Search in DiVA

By author/editor
Kumar, Arvind
In the same journal
Epilepsia
Neurosciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf