Change search
ReferencesLink to record
Permanent link

Direct link
Altered theta coupling between medial entorhinal cortex and dentate gyrus in temporal lobe epilepsy
University of Freiburg, Germany.ORCID iD: 0000-0002-8044-9195
Show others and affiliations
2012 (English)In: Epilepsia, ISSN 0013-9580, E-ISSN 1528-1167, Vol. 53, no 11, 1937-1947 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: Temporal lobe epilepsy is often accompanied by neuron loss and rewiring in the hippocampus. We hypothesized that the interaction of subnetworks of the entorhinalhippocampal loop between epileptic events should show significant signatures of these pathologic changes.

Methods: We combined simultaneous recording of local field potentials in entorhinal cortex (EC) and dentate gyrus (DG) in freely behaving kainate-injected mice with histologic analyses and computational modeling.

Key Findings: In healthy mice, theta band activity was synchronized between EC and DG. In contrast, in epileptic mice, theta activity in the EC was delayed with respect to the DG. A computational neural mass model suggests that hippocampal cell loss imbalances the coupling of subnetworks, introducing the shift.

Significance: We show that pathologic dynamics in epilepsy encompass ongoing activity in the entorhinal-hippocampal loop beyond acute epileptiform activity. This predominantly affects theta band activity, which links this shift in entorhinal-hippocampal interaction to behavioral aspects in epilepsy.

Place, publisher, year, edition, pages
2012. Vol. 53, no 11, 1937-1947 p.
Keyword [en]
Coupled networks, Hippocampus, Kainate, Phase shift, Synchronization
National Category
URN: urn:nbn:se:kth:diva-154863DOI: 10.1111/j.1528-1167.2012.03662.xISI: 000310975400013ScopusID: 2-s2.0-84869074273OAI: diva2:758915

QC 20150331

Available from: 2014-10-28 Created: 2014-10-28 Last updated: 2015-03-31Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Kumar, Arvind
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 19 hits
ReferencesLink to record
Permanent link

Direct link