Challenges of understanding brain function by selective modulation of neuronal subpopulations
2013 (English)In: TINS - Trends in Neurosciences, ISSN 0166-2236, E-ISSN 1878-108X, Vol. 36, no 10, 579-586 p.Article, review/survey (Refereed) Published
Neuronal networks confront researchers with an overwhelming complexity of interactions between their elements. A common approach to understanding neuronal processing is to reduce complexity by defining subunits and infer their functional role by selectively modulating them. However, this seemingly straightforward approach may lead to confusing results if the network exhibits parallel pathways leading to recurrent connectivity. We demonstrate limits of the selective modulation approach and argue that, even though highly successful in some instances, the approach fails in networks with complex connectivity. We argue to refine experimental techniques by carefully considering the structural features of the neuronal networks involved. Such methods could dramatically increase the effectiveness of selective modulation and may lead to a mechanistic understanding of principles underlying brain function.
Place, publisher, year, edition, pages
2013. Vol. 36, no 10, 579-586 p.
IdentifiersURN: urn:nbn:se:kth:diva-154860DOI: 10.1016/j.tins.2013.06.005ISI: 000326063700005ScopusID: 2-s2.0-84884814208OAI: oai:DiVA.org:kth-154860DiVA: diva2:758918
QC 201504172014-10-282014-10-282015-10-06Bibliographically approved