Change search
ReferencesLink to record
Permanent link

Direct link
Antibacterial Properties of Tough and Strong Electrospun PMMA/PEO Fiber Mats Filled with Lanasol-A Naturally Occurring Brominated Substance
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymeric Materials.ORCID iD: 0000-0002-0236-5420
KTH, School of Chemical Science and Engineering (CHE), Fibre and Polymer Technology, Polymeric Materials.
Show others and affiliations
2014 (English)In: International Journal of Molecular Sciences, ISSN 1422-0067, Vol. 15, no 9, 15912-15923 p.Article in journal (Refereed) Published
Abstract [en]

A new type of antimicrobial, biocompatible and toughness enhanced ultra-thin fiber mats for biomedical applications is presented. The tough and porous fiber mats were obtained by electrospinning solution-blended poly (methyl methacrylate) (PMMA) and polyethylene oxide (PEO), filled with up to 25 wt % of Lanasol-a naturally occurring brominated cyclic compound that can be extracted from red sea algae. Antibacterial effectiveness was tested following the industrial Standard JIS L 1902 and under agitated medium (ASTM E2149). Even at the lowest concentrations of Lanasol, 4 wt %, a significant bactericidal effect was seen with a 4-log (99.99%) reduction in bacterial viability against S. aureus, which is one of the leading causes of hospital-acquired (nosocomial) infections in the world. The mechanical fiber toughness was insignificantly altered up to the maximum Lanasol concentration tested, and was for all fiber mats orders of magnitudes higher than electrospun fibers based on solely PMMA. This antimicrobial fiber system, relying on a dissolved antimicrobial agent (demonstrated by X-ray diffraction and Infrared (IR)-spectroscopy) rather than a dispersed and "mixed-in" solid antibacterial particle phase, presents a new concept which opens the door to tougher, stronger and more ductile antimicrobial fibers.

Place, publisher, year, edition, pages
2014. Vol. 15, no 9, 15912-15923 p.
Keyword [en]
electrospinning, antimicrobial/antibacterial, Lanasol, nanofiber toughness, sea algae, poly (methyl methacrylate) (PMMA)/polyethylene oxide (PEO)
National Category
Chemical Sciences
URN: urn:nbn:se:kth:diva-155803DOI: 10.3390/ijms150915912ISI: 000343109700061PubMedID: 25207601ScopusID: 2-s2.0-84908330150OAI: diva2:763058
Sida - Swedish International Development Cooperation Agency

QC 20141113

Available from: 2014-11-13 Created: 2014-11-13 Last updated: 2014-11-21Bibliographically approved
In thesis
1. Micromechanical, Antimicrobial and Filtration Properties of Electrospun Fiber Mats
Open this publication in new window or tab >>Micromechanical, Antimicrobial and Filtration Properties of Electrospun Fiber Mats
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH Royal Institute of Technology, 2014. xiv, 67 p.
TRITA-CHE-Report, ISSN 1654-1081 ; 2014:47
National Category
Polymer Technologies
urn:nbn:se:kth:diva-156091 (URN)978-91-7595-320-5 (ISBN)
Public defence
2014-12-11, K1, Teknikringen 56, KTH, Stockholm, 13:00 (English)

QC 20141121

Available from: 2014-11-21 Created: 2014-11-21 Last updated: 2015-08-21Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Andersson, Richard L.Gedde, Ulf W.Olsson, Richard T.Hedenqvist, Mikael S.
By organisation
Polymeric Materials
In the same journal
International Journal of Molecular Sciences
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 77 hits
ReferencesLink to record
Permanent link

Direct link