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Glyconanomaterials: Emerging applications in biomedical research
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry. University of Massachusetts Lowell, United States .ORCID iD: 0000-0003-1121-4007
2014 (English)In: Nano Reseach, ISSN 1998-0124, E-ISSN 1998-0000, Vol. 7, no 10, 1381-1403 p.Article, review/survey (Refereed) Published
Abstract [en]

Carbohydrates constitute the most abundant organic matter in nature, serving as structural components and energy sources, and mediating a wide range of cellular activities. The emergence of nanomaterials with distinct optical, magnetic, and electronic properties has witnessed a rapid adoption of these materials for biomedical research and applications. Nanomaterials of various shapes and sizes having large specific surface areas can be used as multivalent scaffolds to present carbohydrate ligands. The resulting glyconanomaterials effectively amplify the glycan-mediated interactions, making it possible to use these materials for sensing, imaging, diagnosis, and therapy. In this review, we summarize the synthetic strategies for the preparation of various glyconanomaterials. Examples are given where these glyconanomaterials have been used in sensing and differentiation of proteins and cells, as well as in imaging glycan-medicated cellular responses.

Place, publisher, year, edition, pages
2014. Vol. 7, no 10, 1381-1403 p.
Keyword [en]
glyconanomaterials, carbohydrates, imaging, therapy
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-155794DOI: 10.1007/s12274-014-0507-yISI: 000343083400001OAI: oai:DiVA.org:kth-155794DiVA: diva2:763447
Note

QC 20141114

Available from: 2014-11-14 Created: 2014-11-13 Last updated: 2017-12-05Bibliographically approved

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