Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE credits
A synthetic approach to highly substituted dienes has been investigated. In a four step
synthesis, a wide range of molecules can be formed: Sonogashira coupling between an
alkyne and a bromoalkene, silaboration of the newly formed enyne, Suzuki‐Miyaura
coupling to exchange the boronic ester moiety, and silver(I) oxide activated crosscoupling
to replace the silicon atom. The majority of final compounds are afforded in
moderate to good yields (20‐55% over 4 steps). In some cases, the last step where the
silyl moiety is exchanged to an aromatic ring has caused some problems: isomerization
and lower yields.
2012. , 49 p.