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Behavioural Testing for the Study of Impulsivity in Rats
KTH, School of Computer Science and Communication (CSC).
2014 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

The present work aims to prepare a study that will investigate the role of serotonin in respect to impulsive behaviour in rats. The methodology followed employs behavioural testing, based on operant conditioning, which will be later combined with optogenetic stimulations. The stimulations will be applied to the animals in order to influence their serotonergic system. For the implementation of this project, an experimental set up was built that consists of an operant behavioural box, connected through microcontrollers with a computer and a laser. Also, three different behavioural protocols were designed: Autoshaping, Cue Matching and Peak Interval. Autoshaping has a training character, whereas the other two tasks are used in order to study the different aspects of impulsive behaviour. The results without the laser stimulations that will be obtained from these experimental tasks will be used as control, in order to allow the comparison with the results from the experiments employing the laser stimulations.

Abstract [sv]

Syftet med denna studie är att utforma ett experiment där rollen av serotonerga neuron undersöks under impulsivt beteende i råtta. Metoden vi använt är operant betigning som senare ska kombineras optogenetik. Med optogenitik kan vi styra utsöndringen av serotonin med ljus. För att kunna studera impulsivt beteende, med eller utan denna frisättning av serotonin, introducerade vi djuret för ett beteendeparadigm med eller utan optogenetisk stimulering. Tre olika protokoll utformades, autoshaping, cue matching och peak interval. Protokollet för autoshaping används vid djurets träningsfas (inlärningsfas) medan de två andra användes för att testa olika typer av impulsivt beteende. Resultaten från dessa tre beteendeparadigm utan optogenetisk stimulering har används som baslinje för att kunna undersöka effekten serotonin har på impulsivt beteende.

Place, publisher, year, edition, pages
National Category
Computer Science
URN: urn:nbn:se:kth:diva-156253OAI: diva2:766099
Available from: 2014-11-27 Created: 2014-11-26 Last updated: 2014-11-27Bibliographically approved

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